540 
A  Neiv  Form  of  Calomel. 
f  Am.  Jour.  Pharm. 
August,  19 19. 
The  magnesium  chloride,  sodium  bicarbonate  and  water  are  mixed 
in  a  mortar,  the  precipitated  calomel  added,  and  then  the  glycerite  of 
starch.  Melt  by  gentle  heat  the  anhydrous  lanolin  in  10  Gms.  of 
arachis  oil,  add  the  thymol  and  camphor  previously  dissolved  in 
5  Gms.  of  arachis  oil,  and  while  liquid  add  the  whole  to  the  first 
mixture,  and  heat  until  a  homogeneous  ointment  is  obtained. 
For  the  hypodermic  injection  of  calomel  the  following  formula 
is  given : 
Mercuric  chloride    5.75  grams. 
Hydrochloric  acid  (33.65  per  cent.)    5  drops. 
Glucose   5  grams. 
Sodium  bicarbonate   3 
Crystalline  magnesium  chloride    3.75  " 
Distilled  water    20 
Syrup  to    100  Cc. 
Dissolve  in  a  flask  of  200  Cc.  capacity  the  mercuric  chloride,  by 
warming,  in  the  distilled  water  to  which  the  hydrochloric  acid  has 
been  added,  then  add  the  glucose.  Mix,  in  a  porcelain  capsule,  the 
sodium  bicarbonate  with  about  50  Gms.  of  syrup,  add  the  mag- 
nesium chloride  and  mix.  Now  add  the  mixture  to  the  contents  of 
the  flask.  The  capsule  is  repeatedly  rinsed  with  small  amounts  of 
syrup,  which  are  added  to  the  flask.  Shake  and  warm  on  a  water- 
bath  until  the  evolution  of  gas  has  almost  ceased;  allow  to  cool,  and 
add  sufficient  syrup  to  produce  100  Cc.  This  yields  5  Gms.  of 
calomel  (1  Cc.  =  o.o5  Gms.  of  calomel)  in  extremely  fine  subdivi- 
sion, which  keeps  for  a  long  time  in  suspension. 
To  avoid  the  pain  which  follows  the  injection  of  calomel,  and 
which  is  due  to  the  liberation  of  free  hydrochloric  acid,  the  follow- 
ing modification  is  employed : 
Mercuric  chloride    6.775  grams. 
Hydrochloric  acid  (33.65  per  cent.)    5  drops. 
Glucose    5  grams. 
Sodium  bicarbonate    8.65  " 
Crystalline  magnesium  chloride    10.5 
Distilled  water    25 
Syrup  to    100  Cc. 
Of  the  above,  1  Cc.  corresponds  to  0.06  Gm.  of  calomel. 
