Am.  Jour.  Pharm.  \ 
August,  19 19.  -* 
Current  Literature. 
553 
weight  of  the  latter  used.  It  must  be  remembered  that  one  molecule 
of  atropine  sulphate  is  equivalent  to  two  of  sodium  chloride.  In  the 
case  of  zinc  sulphate  and  copper  sulpfiate,  sodium  sulphate  should  be 
substituted  for  sodium  chloride  in  the  proportion  of  one  of  each  of 
the  sulphates  for  two  of  the  chloride,  and  in  the  case  of  silver  nitrate 
sodium  nitrate  should  be  substituted  for  the  chloride.  (Jour,  de 
Pharm.  de  Belgique,  1,  p.  201,  through  The  Pharm.  Jour,  and 
Pharmacist,  April  12,  191 9.) 
Isotonic  Hypodermic  Injections. — Although  it  has  been 
shown  that  solutions  of  sodium  chloride  varying  in  strength  from 
0.6  to  2  per  cent,  can  be  injected  hypodermically  without  apparent 
harm,  it  is  desirable  to  make  hypodermic  solutions  as  nearly  as  pos- 
sible isotonic  with  human  blood  serum.  Hattie  has  calculated  the 
percentage  of  sodium  chloride  that  must  be  added  to  certain  alka- 
loidal  solutions  in  order  to  obtain  this  result,  and  has  also  determined 
by  experience  the  quantity  actually  necessary;  these  figures  show, 
as  might  be  anticipated,  certain  differences.  The  following  are  the 
percentages  of  sodium  chloride  that  must  be  added  to  the  alkaloidal 
solution,  as  determined  by  actual  experiment :  Morphine  hydro- 
chloride, 1  per  cent.,  0.76;  2  per  cent.,  0.62;  3  per  cent.,  0.43;  1  per 
cent,  -f-  scopolamine  hydrobromide,  0.02  per  cent.,  0.73.  Cocaine 
hydrochloride,  1  per  cent.,  0.74;  6  per  cent.,  o;  0.75  per  cent.  +  ad- 
renalin, 0.005  Per  cent.,  0.79.  Pilocarpine  hydrochloride,  3  per 
cent.,  0.22.  Novocaine,  1  per  cent.,  0.69;  2  per  cent.,  0.51;  1  per 
cent,  -f-  adrenalin,  0.005  Per  cent.,  0.65 ;  2  per  cent,  -f-  adrenalin 
0.005  Per  cent.,  0.47.  Eucaine,  1  per  cent.  +  adrenalin  0.005  Per 
cent.,  0.67.  Atropine  sulphate,  1  per  cent.,  0.79.  Emetine  hydro- 
chloride, 1  per  cent.,  0.82;  3  per  cent.,  0.66;  5  per  cent.,  0.45. 
Arecoline  hydrobromide,  0.5  per  cent.,  0.80.  (Pharm.  Weekbl,  55, 
202,  through  Pharm.  Journ.  and  Pharm.,  April  12,  191 9.) 
The  Fate  of  Quinine  in  the  Organism. — At  most,  40  per 
cent,  of  the  administered  quinine  is  excreted  in  the  urine  and  feces ; 
the  rest  is  not  deposited  in  the  organs  and  must,  therefore,  have 
been  destroyed.  After  intravenous  injection  the  amount  in  the 
blood  sinks  rapidly,  then  more  slowly  to  zero  but  oral  administration 
gives  a  more  constant  quinine  level  which  is  retained  for  about 
twenty-four  hours.  (H.  Hartmann  and  L.  Zila,  Arch.  exp.  Path. 
Pharm.,  83,  221-234,  1918.) 
J.  F.  C. 
