Am.  jour,  pharm.  |    Standardization  of  Piscidia  erythrina. 
Sept.  1 9 19.      -»  J  J 
579 
Sample  No. 
1    0.7  Mils  per  k.  body  weight  of  dog 
2   0.6 
10 
0.5 
0.4 
0.7 
0.5 
0.4 
0.4 
0-5 
0.5 
You  will  note,  therefore,  that  the  average  of  the  above  ten  sam- 
ples is  0.52  Mils  per  k.  We  have,  therefore,  adopted  the  following 
tentative  standard : 
"  Fluid  extract  of  Jamaica  dogwood  should  be  of  such  strength 
that  it  will  produce  incoordination  in  dogs  in  doses  of  0.55  Mils  per 
kilo  body  weight  of  animal  and  should  not  produce  incoordination 
in  doses  less  than  0.5  Mils  per  kilo,  the  drug  being  administered  by 
capsule  after  fasting  the  animal  for  12  hours. 
Fig.  3.  Another  view  of  the  same  dog  as  shown  in  Fig.  1,  one  hour  after 
receiving  dose  of  Jamaica  dogwood.  This  figure  shows  the  animal  when 
severely  affected.  Note  that  the  legs  are  spread  apart  in  order  to  maintain 
balance,  also  the  drooping  of  the  head  and  the  bowed  back. 
The  above  experiment  also  shows  the  wide  variation  in  the 
strengths  of  the  commercial  preparations  on  the  market  and  proves 
the  necessity  for  standardizing  preparations  of  this  drug. 
