Am.  Jour.  Pharm.  | 
October,  19 19.  J 
Chloretone. 
645 
As  a  Local  Anesthetic. — When  chloretone  is  tested  by  some  of 
the  laboratory  methods  used  for  comparing  local  anesthetics  it  is 
found  to  be  surprisingly  effective.  Tested  on  the  sciatic  nerve  of 
the  frog  one  of  the  standard  methods  applied  for  substances  of  this 
character  and  compared  to  cocaine  the  results  are  as  follows  : 
Chloretone. 
0  Min. 
5  Min. 
10  Min. 
15  Min. 
20  Min. 
0.8  per  cent,  solution  
0.2  per  cent,  solution.  .  .  
Cocaine. 
Another  test  applied  to  local  anesthetics  is  to  measure  the  an- 
esthetic action  on  the  frog's  skin.  This  is  always  moist  and  is  com- 
parable to  the  mucous  membrane.  The  test  is  carried  out  by  dip- 
ping one  leg  of  the  frog  into  the  solution  to  be  tested,  leaving  the 
other  undipped  as  a  normal  for  control.  After  contact  for  a  deter- 
mined time  both  legs  are  dipped  into  a  very  dilute  solution  of  HQ 
— about  1-500.  Anesthesia  can  be  measured  by  finding  the  maxi- 
mum dilution  which  is  effective  and  comparing  with  a  solution  of 
cocaine  of  equal  activity.   The  following  results  were  obtained : 
Chloretone. 
Minutes. 
0.8  Per  Cent.  Solution. 
0.4  Per  Cent.  Solution. 
0.2  Per  Cent.  Solution. 
O 
2 
5 
_j_ 
+ 
+ 
8 
10 
15 
+  41  1 
Cocaine. 
Minutes. 
Ji  Per  Cent.  Solution. 
0.5  Per  Cent.  Solution. 
0.2  -  Per  Cent.  Solution. 
O 
2 
s 
8 
10 
-4- 
mr 
± 
15 
Note. — Minus,  — ,  no  anesthesia.  Plus,  +»  complete  anesthesia.  Plus 
minus,  +,  partial  anesthesia. 
