648 
Chloretone. 
f  Am.  Jour.  Pharm. 
^     October,  1919. 
failed  to  develop  in  an  agar-bouillon  medium  but  in  practice  moulds 
occasionally  appear  showing  either  loss  of  chloretone  through  vola- 
tilization or  the  presence  of  a  more  resistant  variety.  It  seems  prob- 
able that  the  occasional  development  of  mould  in  pharmaceutical 
preparations  preserved  with  this  agent  is  due  to  a  deficiency  of  the 
agent  rather  than  a  more  highly  resistant  mould  because  of  failure 
to  obtain  a  saturated  solution  or  a  decrease  in  the  chloretone  con- 
tent from  other  causes. 
It  is  the  purpose  of  this  paper  to  emphasize  two  of  the  properties 
of  chloretone  which  seem  to  be  exceptionally  valuable  and  which 
should  commend  it  to  laboratory  purposes.  First,  as  a  general  an- 
esthetic for  animal  experimentation,  it  has  no  equal  because  of  its 
long-continued  action  and  non-interference  with  the  circulatory  sys- 
tem. Second,  as  a  preservative  where  its  antiseptic  and  germicidal 
action  can  be  relied  upon  to  prevent  the  development  of  bacteria 
and  ultimately  to  kill  the  organisms  which  not  only  impair  the  ap- 
pearance, but  also  destroy  the  valuable  properties  of  organic  solu- 
tions. It  can  be  used  in  many  cases  where  the  preservative  action 
of  alcohol  must  be  eliminated  and  especially  where  sterilization  by 
heat  is  impracticable  because  of  its  destructive  action  on  sensitive 
organic  compounds. 
Bibliography. 
1.  WlLLGERODT. 
1881.    Berichte,  14,  2451. 
2.  Abel  axd  Aldrich. 
1895.    Science,  New  Series,  1,  113. 
3.  Kossa. 
1894-5.    Ungar  Archiv.  f.  Med.  Wiesb.,  3.  350. 
4.  Vamossy. 
Magyar  Orvosi  Archiv.,  Vol.  5. 
5.  Vamossy. 
1897.   Dent.  Med  Woch.;  1897,  Ther.  Beilege,  58. 
6.  HOUGHTOX  AXD  ALDRICH. 
1899.  /.  A.  M.  A.,  33,  777. 
7.  Aldrich  axd  Houghtox. 
1900.  Proc.  Am.  Physiological  Soc,  3,  p.  xxvi. 
8.  Rowe. 
1916.    Jour.  Pharm.  and  Exp.  Therap.,  9,  107. 
9.  Hamilton. 
191 1.   /.  A.  P.  H.  A.,  1,  227. 
10.  Committee  Report,  /.  A.  P.  H.  A.,  July,  1918. 
From  the  Research  Laboratory, 
Parke  Davis  &  Co., 
Detroit,  Mich. 
