Amjine)r'i76arm'}         Analysis  of  Cine  ho- Quinine.  249 
tained  by  drying  a  weighed  sample  at  about  1500  F.,  and  the  ammo- 
nium by  treating  another  portion  of  cincho-quinine  with  boiling  alcohol, 
and  weighing  the  undissolved  portion  as  ammonium  sulphate. 
The  results  of  these  assays,  calculated  for  100  parts  of  material, 
were  as  follows  : 
New  sample.  Old  sample. 
Sulphuric  acid  (S03),  6  516  5-016 
Ammonium  (NHJ,  1-360  1-380 
Water,  determined  by  heat,  4*098  3'174 
Loss  (mainly  water  of  crystallization),        o"359  0*040 
Total  non-alkaloid  matter,    I2'333   9-610 
Quinia,  0*466  0-240 
Quinidia,  1-250  1-820 
Cinchonidia,  0717  0920 
Resin  and  loss,  0*583 
Cinchonia,  i'384  2*440 
Total  am't  dissolved  by  ist  treatment  with  ether,  4*400  5'42° 
Cinchonia  left  undissolved  on  ist  treatm't  with  ether,   83*267  84*970 
The  total  amount  of  cinchonia,  a  portion  of  which  is  combined  with 
sulphuric  acid,  was  therefore  84*651  per  cent,  in  the  new,  and  87*410 
per  cent,  in  the  old  sample,  while  the  quinia  was  present  in  one  case 
to  the  amount  only  of  less  than  one-half,  and  in  one  sample  less  than 
one-quarter  of  1  per  cent. 
Remarks  by  the  Editor. — It  will  be  of  interest  to  recapitulate, 
in  connection  with  the  above  essay,  the  quantitative  results  obtained  in 
previous  analyses,  more  particularly  the  amount  of  the  three  higher 
priced  alkaloids,  present  in  cincho-quinine,  which  form  the  correct 
basis  for  estimating  its  commercial  as  well  as  medicinal  value.  Wenzell 
obtained  2*5  per  cent,  Scheffer  and  Diehl  (see  "Amer.  Jour.  Phar.," 
1875,  p.  205),  from  four  samples,  3*00,  3*25,  2*15  and  3*10  per  cent., 
and  Wells  (4*400 — 1*384=)  3*016  and  (5*420 — 2*440=)  2*980  per 
cent.  ;  the  average  of  these  seven  assays  gives  2*86  per  cent,  of  higher 
priced  cinchona  alkaloids,  from  which  figure  the  lowest  amount  on 
record  differs  by  '71  or  25  per  cent.,  and  the  highest  amount  recorded 
by  *39  or  nearly  14  per  cent.,  while  the  proportion  of  the  lowest  to  the 
highest  figure,  2*15  and  3*25,  is  as  2  :  3. 
A  still  greater  variation  is  observable  in  the  percentage  of  quinia, 
small  as  it  is  ;  the  lowest  one  found  (Wells)  being  '24,  and  the  high- 
