338 
Fluid  Extract  of  Ipecac. 
{Am.  Jour.  Pharm. 
Aug.,  1876. 
of  powder,  length  of  time  in  maceration  previous  to  percolation  (four 
days),  packing  in  conical  glass  percolators,  and  temperature  used  in 
evaporation,  as  directed  by  the  "  Pharmacopoeia."  Calculated  for  16 
troyounces,  which  quantity,  however,  was  not  used  except  in  one  case, 
the  menstrua  and  manipulations  were  as  follows  : 
1st.  Acetic  acid,  f^i  ;  water,  3  parts  ;  alcohol,  1  part.  The  pow- 
der was  moistened  with  the  whole  of  the  acetic  acid,  mixed  with  suf- 
ficient of  the  alcoholic  menstruum  ;  after  maceration  as  above  stated,, 
exhausted  with  the  menstruum  (quantity  obtained  ?— Editor)  ;  the  per- 
colate, after  adding  glycerin  fsi,  was  evaporated  to  1  pt.  and  filtered. 
2d.  U.  S.  P.  menstruum,  exhausted  and  evaporated  to  nearly  solid 
consistence,  added  sufficient  water  to  make  f^viii  ;  then  added  glycerin 
f5i,  the  whole  thrown  upon  a  filter  and  water  passed  through  the  filter 
till  the  filtrate  measured  fsxv,  lastly  added  glycerin  q.  s.  to  make  1  pt. 
After  allowing  it  to  stand  24  hours,  again  filtered. 
3d.  Menstruum  Alcohol. — Percolated  drug  till  half  pt.  of  percolate 
was  obtained  ;  set  this  aside,  and  continued  the  percolation  with  glyce- 
rin and  water,  1  part  of  the  former  to  7  of  the  latter,  until  drug  was 
exhausted  ;  the  two  percolates  were  then  mixed  and  let  stand  for  24 
hours,  the  heavy  precipitate  filtered  out  and  continuously  washed  ; 
filtrate,  after  standing  24  hours,  again  filtered,  the  second  filtrate  evapo- 
rated to  syrupy  consistence,  then  fsviii  alcohol  added  to  separate  gum- 
my matter  ;  evaporated  off  about  two-thirds  of  the  alcohol,  upon  cool- 
ing it  gelatinized. 
4th.  Exhausted  by  U.  S.  P.  process,  threw  the  percolate  into  four  times 
its  bulk  of  water  ;  filtered  at  once,  let  stand  24  hours,  and  again  filtered  ; 
added  the  glycerin  and  evaporated  to  desired  bulk. 
In  each  case  the  amount  of  resinous  extractive  matter,  separated  from 
the  various  percolates  by  evaporation  or  other  means  before  the  pre- 
parations were  completed,  was  carefully  noted  as  follows  : 
From  No.  1,      .  .  840  grains. 
"      "    2,  .  .     160  " 
"      u    3,  .         265    "    (the  unfinished  prep.) 
"      "    4,  .  .  1065  " 
In  order  to  test  the  merit  of  each  menstruum  as  to  its  power  of  ex- 
hausting the  drug,  the  dregs  of  each  operation  above  named  were  ex- 
hausted with  alcohol,  the  percolate  evaporated  to  a  solid  extract  and 
