Am'AJu°g.?i87h6arm'}        Salicylic  Acid— Benzoic  Acid. 
347 
SALICYLIC  ACID. 
BY  FLAVIUS  S.  CASE,  PH.G. 
The  author's  inaugural  essay  treats  of  the  chemical  history  of  salicy- 
lic acid ;  of  its  solubility  in  various  menstrua,  its  medicinal  and  other 
properties.  The  results  of  his  experiments,  made  with  the  view  of 
testing  its  preservative  properties  are  contained  in  the  following  table  : 
Preparation  :    Kept  unchanged  for  the  number  of  days  mentioned  below,  after  dissolving  in  i  fl.oz. 
Pure  Salicylic  Acid.  Glycerin.       £  gr.  Salic 
Prepa-     ,  "  .  '  .  Acid 
ration.    1-32  gr.  1-16  gr.   1-8  gr.   1-4  gr.     1-2  gr.     f 5  1       f  5  ii     f5i  Glyc. 
Mucilago  Acaciae   8  days  50  days  75  days  90  days    20  days  35  days   
Syrupus  Rubi  Idaei  10  days    70  days   
Syr.  Papaveris,  Ph.  Germ.  6  days   12  days    20  days 
Syr.  Limonis   7  days    30  days   
Infus.  Digitalis  10  days    50  days  60  days   
In  each  case  the  experiments  were  made  -with  five  or  six  vials,  all  of 
which  were  uniformly  exposed,  the  temperature  ranging  between  700 
and  900  F. 
BENZOIC  ACID  AS  AN  ANTISEPTIC. 
BY  HENRY  TRIMBLE,  PH.G. 
[Abstract from  an  Inaugural  Essay.) 
For  the  purpose  of  investigating  this  property,  claimed  for  benzoic 
acid,  two  samples  were  employed — one  obtained  by  sublimation, 
according  to  the  U.  S.  P.  process,  and  the  other  purchased  under  the 
name  of  "  artificial "  benzoic  acid,  supposed  to  have  been  prepared 
from  hippuric  acid.  A  good  commercial  salicylic  acid  was  also  pro- 
cured, which,  with  the  above-mentioned  samples,  formed  the  basis  of 
the  following  experiments,  in  one-half  of  which  both  the  sublimed  and 
artificial  benzoic  acids  were  used  and  found  to  be  identical  in  antiseptic 
power  ;  the  remaining  experiments  were  therefore  made  with  the  arti- 
ficial acid  only.  The  results  of  the  writer  are  condensed  in  the  fol- 
lowing table  : 
One  part  of 
Salicylic 
acid 
Benzoid 
acid 
2000  parts 
Infus.  Buchu 
Spoiled  in  i 
days 
Remained 
unaltered 
after  60 
days 
4000  parts 
Inf.  Buchu 
Spoiled  in  4 
days 
Spoiled  in  16 
days 
8000  parts 
Inf.  Buchu 
Spoiled  in  5 
days 
2000  parts 
Inf.Colombo 
Spoiled  in  6 
days 
Cloudy,  but 
no  change 
of  color  in 
16  days 
2000  parts 
Inf.  Gentian, 
simpl. 
Spoiled  in  19 
days 
Unaltered 
after  30 
days 
1000  parts 
Solution  of 
Albumen 
4000  parts 
Solution  of 
Albumen 
[1  in  16  water  J 
Spoiled  in  12 
days 
Unaltered 
after  60 
days 
Spoiled  in  10 
days 
Spoiled  in  19 
days 
