Amsep^'i87h6!rn9'}  Contributions  from  the  School  of  Pharmacy,  etc.  387 
mixtures  warmed  on  the  water-bath,  the  nicely  settled  precipitates- 
gathered  and  washed  on  small  tared  filters  and  so  dried  at  near  100°  F. 
The  weight  of  precipitate  in  each  case  came  very  near  to  0*020  gram.. 
Again,  0*025  gram  of  the  purified  alkaloid  was  taken,  and  the  precipi- 
tate found  to  weigh  0*0495  gram. 
Secondly,  by  noting  carefully  the  number  of  cc.  of  Mayer's  standard 
solution1  required  in  obtaining  the  precipitates — then  obtaining  the 
weight  of  the  clean,  dry  precipitates — it  was  ascertained  that  1  cc.  of 
the  solution  precipitates  0*0425  gram  of  berberina,  weighed  as  base.. 
The  volumetric  determination  is  slow,  from  the  length  of  time  required 
for  the  precipitate  to  settle  after  each  addition  of  reagent.  Traces  of 
precipitate  are  observed  by  placing  a  drop  on  a  blue  or  black  glass 
slide. 
V.  Examination  of  the  "  Retinoids"  Sanguinarin,  Leptandrin  and  Aconitin.  By 
J.  R.  Little,  Ph.C. 
Firstly,  as  a  means  of  comparing  the  samples  of  different  manufac- 
tures, and  as  some  indication  of  their  constituents,  the  following  de- 
terminations of  solubilities  were  made  : 
SANGUINARIN — 0*500  GRAM  TAKEN. 
No.  1.  No.  2.  No.  3. 
Residue  insoluble  in  25  cc.  water,      .           .           .      0*327  0*346  °'357 
11         "            10  cc.  alcohol,            .           .            0*140  0*205  0*294 
"         "            10  cc.  Decinormal  Solution  ofPotassa,  0*331  0*312  0*389 
"         "            10  cc.  Ether,2        .           .           .      0*163  0*345  0-330 
LEPTANDRIN — O50O  GRAM  TAKEN. 
No.  1. 
No.  2. 
No..  3. 
No.  4. 
Residue  insoluble 
in  25  cc.  water, 
0*310 
0*183 
0*1*90 
0*224 
«  « 
10  cc.  alcohol, 
0-155 
0*265 
0*094 
0*193 
U  (( 
10  cc.  Decinormal  Solu- 
tion of  Potassa, 
0*2O2 
o-33* 
0*078 
0*140 
«  «« 
10  cc.  Ether,2 
0*l87 
0*3 16 
0*2.17 
O'l  16 
By  Schiel's  method  3  for  the  extraction  of  the  alkaloid  from  blood- 
root,  sanguinarin  No.  I  was  found  to  contain  of  the  alkaloid  sanguinarina, 
6*2  per  cent.     By  another    method    sanguinarin  No.  3  was  found 
1  J3"546  grams  mercuric  chloride,  and  49*8  grams  potassium  iodide,  in  water  to 
make  one  litre. 
2  The  filtrate  was  made  to  measure  10  cc. 
3"Husemann's  PflanzenstofFe,"  S.  200. 
