464  Crystallized  Hydrobromate  of  Conia.  {Am'Jc°",r,I£h6aim' 
solidified  to  a  soft  crystalline  mass  when  cold,  from  the  camphor  crys- 
tallizing. It  is  most  probable  that  the  camphor  is  the  solvent,  which 
would  also  seem  likely,  as  camphor  is  an  essential  oil,  and  is  known  to 
render  other  bodies  fluid.  The  change  of  color,  with  the  formation  of 
an  oily  liquid,  would  seem  to  point  to  chemical  action  occurring  when 
the  mixture  is  subjected  to  strong  heat. 
The  following  notes  of  the  solubility  of  the  mixture  in  various  arti- 
cles may  be  serviceable  to  any  who  are  called  upon  to  dispense  it,  or 
to  physicians  who  feel  inclined  to  try  the  effects  of  it. 
It  is  miscible  in  all  proportions  with  alcohol,  sp.  gr.  '838,  bisulphide 
of  carbon,  ether  and  olive  oil.  It  is  soluble  in  eleven  parts  of  alco- 
hol, sp.  gr.  '937.  It  is  insoluble  in  water.  It  forms  a  clear  mixture 
with  one  and  a-half  parts  of  chloroform,  but  a  further  addition  of  three 
parts  of  chloroform  renders  it  turbid.  Camphor  forms  a  permanent 
liquid  with  three  times  its  weight  of  chloral  hydrate.  The  experi- 
ments were  conducted  with  the  atmosphere  at  a  temperature  of  about 
8o°  ;  the  fact  is  mentioned  as  fit  may  have  influenced  the  solubility 
slightly. — Phar.  Jour,  and  Trans.,  July  29,  1876. 
CRYSTALLIZED  HYDROBROMATE  OF  CONIA.1 
BY   M.  MOURRUT. 
In  a  paper  recently  read  before  the  Society  de  Therapeutique  the 
author  described  some  attempts  to  obtain  crystalline  salts  of  conia. 
His  first  experiments  were  made  with  various  acids  upon  the  ordinary 
brown  conia,  from  which  crystals  were  obtained,  but  they  were  con- 
taminated by  a  brown  matter  which  could  not  be  removed  without 
great  loss.  The  German  conia,  which  is  nearly  white,  was  therefore 
substituted,  and  this  readily  gave  crystals.  The  salt  obtained  most 
easily  was  the  hydrobromate,  by  simply  treating  the  alkaloid  with  the 
acid.  When  brown  conia  was  operated  on  there  was  a  rise  of  tem- 
perature, an  evolution  of  white  vapors,  and  the  characteristic  odor  of 
conia  became  manifest ;  thej  mixture  then  became  green,  and  finally 
black  with  a  reddish  tinge.  After  a  short  time  crystals  commenced  to 
form  ;  they  were  contaminated  by  the  brown-black  substances  that 
colored  the  liquid,  but  by  repeated  crystallizations  they  were  obtained 
colorless.    There  was,  h  wever,  much  loss  with  the  impure  alkaloid. 
In  operating  upon  the  v.  ■  te  conia  the  author  places  it  in  a  crystalliz- 
xRepertotre  de  Pharmacie,  June  25,  p.  . 369. 
