IODO-SULPHATES  OF  THE  CINCHONA  ALKALOIDS.  251 
All  the  alkaloids  were  furnished  in  a  most  obliging  manner 
by  Mr.  John  Elliott  Howard,  to  whom  the  author  is  deeply  in- 
debted for  them,  and  thus  publicly  desires  to  express  his  ac- 
knowledgements ;  many  of  these  various  alkaloids  having  taken 
more  than  ordinary  trouble  in  the  preparation  and  purifica- 
tion. 
It  is  well  known  that  quinine  and  quinidin,  under  the  con- 
tinued effect  of  heat  and  dilute  sulphuric  acid,  undergo  a  mole- 
cular change  into  quinicine,  which  M.  Pasteur  has  asserted  to  be 
isomeric  with  the  original  alkaloids,  but  hitherto  no  complete 
analysis  has  been  made  of  the  metamorphosed  alkaloids. 
The  author  has  produced  an  iodo-sulphate  of  quinicine,  but  it 
is  no  longer  a  crystalline  compound ;  it  presents  itself  as  a  deep 
blood-colored  resin,  very  soluble  in  spirit  and  readily  precipi- 
tated by  water  from  its  spirituous  solution.  This  substance  has 
not  yet  been  submitted  to  analysis.  During  the  production  of 
the  iodo-sulphate  of  quinidin  a  certain  portion  of  the  alkaloid 
becomes  converted  into  quinicine,  as  may  be  demonstrated  by 
the  production  of  this  resinous  compound  from  the  mother-liquid 
on  the  addition  of  further  proportion  of  iodine. 
Cinchonine  and  cinchonidin  become  converted  into  cinchoni- 
cine  by  similar  treatment,  and  this  amorphous  uncrystalline 
alkaloid  also  forms  a  resinous  iodo-sulphate ;  its  color  is  deep 
purple-black,  and  it  deposits  itself  on  spontaneous  evaporation 
of  the  spirit,  or  on  the  cooling  of  a  highly  concentrated  spiritu- 
ous solution,  in  small  drops,  highly  tenacious  at  100°  Fahr., 
but  becoming  solid  at  60°  Fahr.  This  compound  has,  in  a 
fine  state  of  division,  a  beautiful  purplish-blue  color,  and  such 
a  film  generally  forms  around  the  edge  of  the  vessel  in  which  it 
is  produced. 
Cinchonicine  appears  to  be  one  of  the  products  during  the 
manufacture  of  the  iodo-sulphate  cinchonidin,  but  there  is  a 
much  larger  production  of  it  during  the  formation  of  the  cin- 
chonine salt. — Proceedings  of  the  Royal  Society ;  from  the  Lon- 
don Pharmaceutical  Journal,  March,  1858. 
