Am-£^-P9h5arm-}      Some  Derivatives  of  Chimaphilin.  241 
which  he  gave  the  formula  C10H19O,  this  principle  showed  so  much 
resemblance  in  solubility  to  the  same,  that  a  combustion  was 
deemed  necessary  to  prove  or  disprove  their  identity. 
The  results  of  such  analysis  were  : 
Average  Found.  Calculated  for  Ci0H19O 
Per  Cent.  Per  Cent. 
Carbon                                                        77*53  77 '42 
Hydrogen  11*25  12-25 
Oxygen                                                         11*22  io'33 
100  "oo  IOO'OO 
By  not  melting  at  2500  C„  by  corresponding  solubility,  and  by 
some  general  properties,  the  principle  also  showed  a  similarity  to 
the  "  glistening  crystals  "  described  by  Peacock;  but  as  the  result 
of  a  combustion  of  the  same,  he  reported  several  per  cent,  more  of 
carbon  than  the  writer  found. 
A  collection  of  the  species  metadata  was  made  on  November  12, 
1894,  near  Haddonfield,  New  Jersey.  About  1  kilo,  of  the  whole 
plant  was  at  once  macerated  with  water,  which  was  distilled  off 
without  delay.  Crystals  of  chimaphilin  were  obtained  in  the  dis- 
tillate. Peacock  (vide  loc.  citi)  did  not  obtain  chimaphilin  from  fresh 
Chimaphila  maculata  gathered  in  the  same  locality  in  July,  1 89 1. 
His  reason  for  stating  it  absent  was  that  "  no  solid  separated  in 
the  condenser,  nor  in  the  distillate,  even  upon  allowing  the  latter  to 
stand  for  a  month."  In  view  of  the  fact  that  chimaphilin  is  slightly 
soluble  in  water,  and  under  the  circumstance  of  no  mention  by  him 
of  having  shaken  the  distillate  with  ether  or  other  solvent  to  sepa- 
rate the  small  amount  that  is  soluble,  such  traces  might  have 
escaped  his  notice.  Upon  allowing  another  portion  of  the  same 
collection  to  dry  in  the  air  of  a  room  for  forty  days,  he  was  enabled 
to  detect  the  principle  by  the  usual  method. 
Some  Chimaphila  umbcllata  was  gathered  at  St.  Davids,  Penn- 
sylvania, on  December  12,  1894.  Crystals  of  chimaphilin  were 
obtained  when  the  fresh  drug  was  subjected  to  the  usual  distillation 
process.  From  the  difference  in  the  experience  of  Mr.  Peacock  and 
the  writer,  the  latter  is  led  to  believe  that  the  amount  of  chimaphi- 
lin present  in  the  fresh  herb  depends  upon  the  time  of  collection. 
The  writer  is  much  indebted  to  Messrs.  Peacock  and  Manger  for 
the  Chimaphila  umbellata,  from  which  the  chimaphilin  was 
prepared. 
