558 
Granulated  Opium. 
(  \  m.  Jour.  Pharm. 
\  November,  1895. 
ing  from  0-3  to  06  per  cent.,  which  loss  can  be  reduced  by  lengthen- 
ing the  time  of  percolation.  The  U.  S.  P.  process  requires  from  60 
hours  to  6  days,  with  a  loss  of  from  1-4  to  2-42  per  cent,  of 
morphine. 
While  this  work  was  being  undertaken  inquiries  were  also  made 
at  a  number  of  retail  drug  stores,  in  order  to  ascertain  the  extent  of 
the  use  of  the  official  process.  Only  a  small  percentage  of  the 
persons  interrogated  follow  the  process  strictly;  the  majority  do  not 
use  it  at  all,  preferring  to  exhaust  the  drug  in  a  more  speedy  and 
thorough  manner.  Some  persons  use  it  with  the  addition  of  sand 
or  sawdust  to  hasten  the  percolation,  in  which  case  the  precipitated 
calcium  phosphate  might  just  as  well,  or  better,  be  omitted ;  this, 
however,  was  not  done ;  the  few  who  use  the  process  expressed 
themselves,  in  most  cases,  as  being  dissatisfied  with  it. 
The  processes  of  the  U.  S.  P.  should  in  all  cases  be  the  best 
obtainable  for  their  respective  preparations.  This  is  not  the  case 
with  the  process  for  tincture  of  opium,  but  it  is  hoped  that  a  change 
will  be  made  when  the  time  comes,  and  we  sincerely  hope  that 
granulated  opium  will  be  the  form  of  drug  officially  authorized. 
table;  of  comparative  results. 
Process  Used. 
U.  S.  P.  1890  .  .  . 
U.  S.  P.  1890  .  .  . 
Granulated  opium 
Granulated  opium 
Granulated  opium 
Granulated  opium 
Granulated  opium 
Granulated  opium 
Granulated  opium 
Granulated  opium 
Granulated  opium 
U.  S.  P.  1890  .  .  . 
U.  S.  P.  1890   .  .  . 
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0-65 
12  hours 
1-375 
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12  hours 
1-355 
0-15 
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1-390 
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12  hours 
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—  tn  to 
6  days 
2  days 
10  hours 
6  hours 
10  hours 
10  hours 
10  hours 
24  hours 
24  hours 
10  hours 
24  hours 
3  days 
4  da3's 
305  Cherry  Street,  Philadelphia. 
