^"Mariss?"^™  }     Fluid  Extracts  of  the  New  Pharmacopoeia.  125 
sample  prepared  at  the  same  time,  and  differing  only  in  containing 
twenty  per  cent,  of  glycerin,  appears  to  be  even  more  changed  than  the 
first,  with  a  much  larger  sedimentary  deposit.  It  is  evident  that  thi& 
preparation,  to  be  made  permanent,  requires  a  more  alcoholic  men- 
struum, and  a  mixture  of  three  parts  of  alcohol  and  one  part  of  water^ 
with  ten  per  cent,  of  glycerin  in  the  first  one  hundred  parts,  is  sug- 
gested as  being  likely  to  accomplish  that  object ;  should  this  also  fail, 
it  may  even  be  necessary,  as  in  the  case  of  cotton  root,  to  omit  the 
water  entirely. 
ExTR ACTUM  Glycyrrhiz^.  PYuidum. — Fluid  Extract  of  Glycyr- 
rhiza. — The  fluid  extract  of  liquorice  root  of  the  Pharmacopoeia  of 
1870,  was  prepared  with  a  menstruum  composed  of  eight  fluidounce& 
of  alcohol,  three  fluidounces  of  glycerin,  and  five  fluidounces  of 
water;  finishing  the  percolation  with  diluted  alcohol,  and  adding  one 
fluid  ounce  of  glycerin  to  the  dilute  percolate  before  evaporating.  The 
present  Pharmacopoeia  directs  diluted  alcohol,  with  three  per  cent,  of 
water  of  ammonia  in  the  first  one  hundred  parts  of  menstruum,  and 
three  per  cent,  more  in  the  dilute  percolate  previous  to  evaporation. 
The  Philadelphia  College  of  Pharmacy  recommended  a  menstruum 
composed  of  one  part  of  alcohol,  and  three  parts  of  water,  with  twenty 
per  cent,  of  glycerin,  and  five  per  cent,  of  water  of  ammonia  in  the 
first  one  hundred  parts.  A  sample  thus  prepared  in  December,  1879, 
now  contains  only  the  slight  precipitate  which  formed  soon  after  it  was 
made,  and  in  all  other  respects  it  is  in  excellent  condition.  In  regard 
to  the  officinal  formula,  the  utility  of  adding  a  portion  of  the  water  of 
ammonia  to  the  dilute  percolate  is  not  apparent,  it  would  seem  to  be 
more  advantageous  to  add  all  that  is  used  to  the  menstruum,  so  that 
its  solvent  action  may  be  exercised  on  the  drug ;  neither  does  it  appear 
necessary  to  use  as  strong  a  menstruum  as  diluted  alcohol.  A  men- 
struum containing  as  little  as  twenty  per  cent,  of  alcohol,  has  been 
recommended  by  an  operator  of  the  greatest  ability ;  as  water  alone 
will  exhaust  liquorice  root,  the  chief  use  of  alcohol  in  the  fluid  extract 
is  as  a  preservative ;  regarding  the  use  of  glycerin  in  this  preparation, 
it  is  possible  that  ten  per  cent,  might  be  sufficient,  although  a  sample 
made  with  that  proportion  precipitated  considerably  more  than  the 
sample  containing  twenty  per  cent. 
ExTR ACTUM  GossYPii  Radicis  Fluidum. — Fluid  Extract  of  Cotton 
Root. — For  this  preparation  the  Pharmacopoeia  of  1870  directed  a 
menstruum  composed  of  eight  fluidounces  of  alcohol,  three  fluid- 
