Am.  JourPliarni.  \ 
Mar.,  1883.  j 
FJiarmaGeutlml  Notes. 
Kiew  against  headache  is  prepared  from  oil  of  peppermint  3ss,  vola- 
tile oil  of  mustard,  gtt.  vj,  camphor  gr.  x,  ether  ^j,  alcohol  Siij,  and  suf- 
ficient tincture  of  peppermint  or  of  melissa,  to  impart  the  desired  shade 
of  color— J.  K.  Mueller,  Phar.  Zeitschr.  Russl.  1882,  p.  78:3. 
Compound  Tincture  of  Cajuput. — Oil  of  peppermint,  oil  of  cloves, 
oil  of  cajuput,  oil  of  anise  aa  ^j,  alcohol  ^jv.  Mix.  It  is  a  powerful 
stimulant. — Eefec.  Med.  Jour.,  1883,  p.  45. 
PHAEMACEUTICAI.  NOTES. 
By  R.  F.  Fairthorne,  Ph.G. 
Terbromide  of  Arsenic  and  the  Solutio7i  of  same. — The  solution  of 
this  substance  has  obtained  some  celebrity  on  account  of  having  been 
found  to  act  in  a  beneficial  manner  in  the  treatment  of  diabetes.  Hav- 
ing had  occassion  to  prepare  it,  I  thought  it  might  be  of  interest  to 
readers  of  this  Journal  to  give  a  short  account  of  the  method  employed 
by  me.  The  terbromide  of  arsenic  was  made  in  the  following  manner  : 
Take  of 
Metallic  arsenic,        ...  77  grains. 
Bromine,   .         .         .  .         .     240  " 
Having  placed  the  bromine  in  the  bottom  of  a  long  test-tube 
immersed 'in  ice  water,  add  the  arsenic  in  powder  in  small  portions  at  a 
time,  agitating  gently  after  each  addition,  and  allowing  the  mixture  to 
become  cool  before  adding  more  of  the  metal ;  after  the  whole  has  been 
put  into  the  tube,  close  this  with  a  cork,  remove  from  the  water,  and 
occasionally  agitate  during  six  hours;  then  pour  into  a  suitable  glass- 
stoppered  vial.  Terbromide  of  arsenic  is  a  dense,  orange-colored  liquid, 
slightly  volatile  at  ordinary  temperatures,  but  entirely  so  by  applica- 
tion of  heat  with  the  production  of  yellow  pungent  fumes. 
The  solution  referred  to  is  made  by  taking  of 
Terbromide  of  arsenic,        .         .         100  grains. 
Distilled  water,  .         .  .         .10  fiuidounces. 
Mix  and  dissolve. 
This  forms  a  canary-colored  liquid  having  an  odor  that  recalls  that 
of  chloral.  The  dose  which  has  usually  been  given  has  been  two 
drops,  containing  the  twenty-fonrth  of  a  grain  of  the  arsenical  salt, 
repeated  every  four  hours. 
In  preparing  the  terbromide  great  caution  is  necessary,  as  the  action 
of  bromine  on  arsenic  is  very  violent,  and  unless  great  care  is  taken,  so 
much  heat  is  produced  upon  the  addition  of  the  metal  that  it  becomes 
red  hot,  and  copious  fumes  of  the  bromide  of  arsenic  are  given  off, 
which  of  course  are  very  poisonous. 
