Am.  Jour.Pharm. ) 
April,  1883.  J 
Qwinium  SaiU 
175 
added  or  not.  The  result  is  not  altered  when  two  ms.  of  tannin  are 
added  to  one  m.  of  the  sulphate,  under  the  same  conditions  in  other 
respects.  The  acetate,  although  it  does  not  seem  to  enter  the  product, 
yet  facilitates  the  combination  and  filtration  to  such  a  degree  as  to  ren- 
der it  a  valuable  adjuvant  in  the  process.  When  the  reaction  is  com- 
plete, no  uncompounded  tannin  or  quinium  sulphate  exists  in  the 
filtrate.  The  new  compound  is,  however,  slightly  soluble  in  water.  It 
has  a  distinctly  crystalline  form,  the  feathery  lightness  of  quinium 
sulphate,  and  the  color  of  gallic  acid.  It  is  very  soluble  in  hot  alcohol, 
from  which  most  of  it  again  separates  on  cooling.  The  hot  alcoholic 
solution,  when  diluted  with  water  lets  fall  the  compound  in  amorphous 
flakes,  which  on  standing  contract  and  resume  the  crystalline  condition. 
Since  the  uniformity  of  the  product  manifested  itself  under  so  many 
varied  conditions,  and  since  a  definite  amount  of  material  was  wholly 
consumed  in  its  generation,  the  formula  of  the  compound  may  be 
written  (QnH)2S04,HTn.  Aq.  with  a  molecular  weight  of  1086.  The 
writer  holds  the  opinion  that  this  quinium  sulpho-tannolate  should 
replace  all  the  other  indefinite  so-called  tannates  of  quinine.  It  can 
be  very  easily  prepared  by  the  following  formula : 
Quinium  sulphate       ....  872  parts. 
Tannin    .  .  .  .  .  .      322  " 
Potassic  acetate  .  .  .  .  98  " 
"Water  sufficient. 
Dissolve  the  tannin  and  potassic  acetate  in  10,000  parts  of  water, 
with  heat,  then  add  the  quinium  sulphate,  continue  the  heat  for  a  few 
minutes,  transfer  the  precipitate  to  a  filter,  and  after  sufficient  washing 
dry  it  by  exposure  in  the  open  air. 
Syrup  of  yerba  santa  is  growing  in  popularity  as  a  vehicle  for 
quinine  in  a  tasteless  form.  As  ordinarily  prepared,  it  represents  one 
ounce  of  the  leaves  in  the  pint.  But  this  is  stronger  than  need  be  for 
general  purposes,  and  hence  a  syrup,  containing  half  an  ounce  in  the 
pint  is  a  better  form.  The  active  agent  is  an  acid  resin  which  gener- 
ates a  nearly  insoluble  salt  with  quinine.  This  has  the  similarity  of 
quinium  tannolate,  but  differs  from  it  in  being  a  regular  salt,  which  is 
readily  soluble  in  ammonia,  and  decomposed  by  the  common  acids  into 
the  free  acid  resin  and  soluble  quinium  salt.  The  resin  may  be  named 
eriodictyonic  acid.  It  is  dark  brown  in  color,  and  has  the  flavor  and 
odor  of  the  leaves.  It  is  soluble  in  alcohol,  and  acts  on  hydrosodic 
<iarbonate  with  effervescence,  producing  sodium  eriodictyonate.  This 
