^Va°n,''i?7^''"''}  Action  of  Lohelina  on  the  Circulation.  127 
from  it  which  are  manufactured  by  this  company,  are  wan  anted  to  be 
produced  without  the  employment  of  arsenic,  and  to  be  entirely  free 
from  this  poisonous  reagent. 
The  Berlin  Company  are  working  Coupier's  process  with  several 
important  modifications,  and  produce  from  200  to  300  kilogs.  of  fuchsin 
per  diem.  Some  specimens  of  fuchsin  and  other  colors  manufactured 
by  this  company  appear  to  be  products  of  unrivalled  beauty,  purity  and 
strength.  The  fuchsin  is  stated  to  be  not  only  purer,  but  stronger  than 
that  made  by  the  aid  of  arsenic  acid,  and  is  the  pure  hydrochlorate  of 
rosanilin.  The  rosanilin  base,  from  its  great  purity,  is  admirably 
adapted  for  the  preparation  of  anilin  blue,  and  is  largely  used  by  other 
manufacturers  of  anilin  colors. 
Being  free  from  arsenic,  these  dyes  are  not  only  fitted  for  coloring 
sweetmeats,  liqueurs,  syrups,  and  pharmaceutical  preparations  of  every 
description,  but  may  be  used  in  many  other  industrial  purposes  where 
poisonous  colors  would  be  more  or  less  dangerous,  as  in  the  staining  of 
paper,  paper-hangings,  toys,  &c. 
It  is  to  be  desired  that  other  manufacturers  of  these  dyes  will  adopt 
the  new  method,  and  relinquish  the  old  arsenic  acid  process,  which, 
apart  from  the  inconveniences  it  has  caused  both  manufacturers  and 
consumers,  has  led  to  many  lamentable  accidents. — Chem.  Nnus 
\_Lond,\  Feb.  5,  1875. 
ACTION  OF  LOBELINA  ON  THE  CIRCULATION. 
Dr.  J.  Ott,  of  Easton,  Pa.,  has  experimented  with  this  alkaloid, 
which  was  prepared  by  Messrs.  Hance  Bros.  &  White,  after  the  process 
of  Professor  Procter.  The  experiments  were  made  upon  rabbits,  cats 
and  dogs,  the  author  arriving  at  the  following  conclusions  : 
"  Reasoning  from  the  above  data,  the  inference  would  be  that  lobe- 
lina  in  small  doses  increases  the  blood  pressure  by  acting  as  an  excitant 
on  the  peripheral  vaso-motor  system.  The  pulse  seems  temporarily 
reduced  and  then  increased  ;  the  necessarily  limited  number  of  our 
experiments  precludes  saying  more  about  it.  I  will  state  here  that  I 
have  found  lobelia  to  be  mainly  a  respiratory  poison,  and  that  in  the 
cat  it  greatly  reduces  the  temperature.  The  above  experiments  on 
lobelina  were  made  in  Professor  Bowditch's  Physiological  Laboratory 
at  Harvard  Medical  School  ;  to  him  I  am  indebted  for  opportunities  of 
study  and  many  highly  important  suggestions  in  the  investigation." — 
Boston  Med.  and  Surg,  your..,  1 875,  Feb.  4. 
