146  Chemical  Examination  of  Cincho-^inine,\^'^'^^^(;^^l'^' 
sional  standard,  the  nostrum  was  regarded  with  suspicion,  and  very 
shortly  after  its  introduction  it  was  subjected  to  chemical  examination. 
We  are  cognizant  only  of  two  such  examinations  ;  one,  made  in  1870 
by  Mr.  Wm.  T.  Wentzel ;  the  other,  read  by  Mr.  Albert  E.  Ebert 
before  the  American  Pharmaceutical  Association  at  its  meeting  in  1874,, 
from  which  it  appears  that  neither  of  the  experimenters  succeeded  in 
determining  the  presence  of  quinia.  The  reading  of  Mr.  Ebert's 
paper  before  the  American  Pharmaceutical  Association  prompted  the 
manufacturers  of  the  nostrum  to  protest  against  its  publication  in  the 
Proceedings  of  that  body,  unless  such  publication  was  complemented  by 
certain  explanations,  and  the  certificates  of  several  chemists  (employed 
by  the  manufacturers),  that  the  article  contained  quinia.  The  Amer- 
ican Pharmaceutical  Association  having  thus  become  involved  in  a  con- 
troversy, the  merits  of  which  remained  undecided,  we,  being  con- 
nected with  the  Association,  and  having  become  interested  in  the  ques- 
tion, have  endeavored  by  the  experiments  detailed  in  the  following 
pages  to  place  the  substance  called  "  Cincho-Quinine  "  before  the  pub- 
lic on  its  true  merits. 
We  used  for  our  experiments  four  samples  of  cincho-quinine,  which 
are  severally  designated  in  our  paper  as  No.  i.  No.  2,  No.  3  and 
No.  4. 
Sample  No.  i  was  purchased  by  E.  SchefFer  in  March,  1874,  and 
consisted  of  part  of  a  bottle  at  the  date  of  our  examination. 
Sample  No.  2  was  purchased  for  our  examinations.  It  had  been 
obtained  from  the  manufacturer  by  the  wholesale  drug  house  from 
which  we  bought  it,  some  time  in  May,  1874.  The  sealed  bottle  was 
enveloped  in  a  circular,  covered  with  a  blue  wrapper,  and  was  labeled. 
The  circular  will  be  described  in  an  appendix,  as  Circular  No.  i. 
Sample  No.  3  was  purchased  by  C.  Lewis  Diehl  on  the  i8th  of  Sep- 
tember, 1874,  and  consisted  of  part  of  a  bottle  at  the  date  of  our 
examination. 
Sample  No.  4  was  also  purchased  for  our  examinations.  It  had  been 
obtained  from  the  manufacturer  by  the  wholesale  drug  house  from 
which  we  bought  it,  earlv  in  December,  1874.  The  sealed  bottle  was 
enveloped  in  a  circular,  covered  with  a  blue  wrapper,  and  was  labeled. 
The  circular  will  be  described  in  the  appendix  as  Circular  No.  2. 
SERIES  OF  EXPERIMENTS,  I. 
The  physical  appearance  of  cincho-quinine,  as  well  as  the  statement 
of  its  manufacturers,     that  it  is  composed  wholly  of  the  bark  alka- 
