Pharm. 
152  Chemical  Examination  of  Cincho-^inine\^'^'^^^^i^^l 
EXPERIMENTS  B. 
B  I. — The  precipitate  A  2  was  triturated  to  a  fine  powder,  and 
4-513  grams  of  it  introduced  into  a  flask  and  agitated  with  stronger 
ether  frequently  during  twenty-four  hours.  The  contents  of  the  flask 
were  then  transferred  to  a  filter,  the  filtrate  was  collected  in  a  tared 
beaker,  and  the  residue  on  the  filter  washed  with  ether  until  about 
four  fluidounces  of  filtrate  and  washings  were  obtained.  These  were 
allowed  to  evaporate,  spontaneously,  at  first,  and  then  on  a  water  bath,, 
until  the  residue  no  longer  lost  weight.  It  weighed  0*254  grams,, 
which,  calculated  for  the  entire  quantity  of  precipitates,  A  2  (4*559 
grams),  corresponds  to  0*2565  grams  of,  in  ether,  soluble  alkaloids,, 
from  5*o  grams  of  cincho-quinine,  or  5*130  per  cent. 
Quantitative  result  No.  5. — Cincho-quinine^  sample  No.  2,  contains  of  in 
ether soluble  alkaloids  5*130  per  cent. 
Remarks. — The  ethereal  solution  B  r,  during  the  spontaneous  evap- 
oration, deposited  crystals  on  the  sides  of  the  beaker  until  about  two- 
thirds  had  evaporated  \  after  which  there  was  no  longer  any  crystalline 
formation,  or  deposit,  until  it  was  evaporated  to  complete  dryness^ 
when  the  bottom  of  the  beaker  was  covered  with  a  yellowish-white 
resino-crystalline  residue. 
We  attempted  to  redissolve  the  entire  residue  with  twenty-five  parts 
of  stronger  ether,  but  found  it  very  slowly,  and  with  difiiculty,  soluble 
in  that  solvent,  and  consequently,  abandoned  the  experiment.  Had 
this  residue  consisted  of  quinia  only,  it  would  have  readily  dissolved  in 
from  12  to  15  parts  of  stronger  ether. 
B  2. — The  ethereal  residue,  B  i,  was  dissolved  in  100  drops  of  alco- 
hol of  60  per  cent.,  containing  5  per  cent,  of  sulphuric  acid  \  tincture 
of  iodine  was  added  in  slight  excess,  and  the  liquid  heated  gently,  to 
redissolve  the  very  copious  red-brown  precipitate  which  had  been, 
formed.  The  solution  was  then  set  aside  for  40  hours,  when  a  mix- 
ture of  herapathit  and  of  a  red-brown  crystalline  precipitate  had  formed. 
This  mixture  was  collected  on  a  filter,  washed  with  dilute  alcohol,  and 
dried.  It  weighed  0*067  grams.  The  filtrate  and  washings,  on  spon- 
taneous evaporation,  deposited  a  very  small  additional  quantity  of  hera- 
pathit. This  was  carefully  collected,  and,  together  with  the  previously 
obtained  and  weighed  precipitate,  dissolved  in  boiling  alcohol,  the  solu- 
tion filtered,  allowed  to  evaporate  at  a  gentle  heat  to  a  small  volume,, 
and  allowed  to  stand  at  rest  for  18  to  24  hours.  Well  defined  crys- 
tals of  herapathit,  exhibiting  the  characteristic  bronze-green  color,  had 
