1 60  Chemical  Examination  of  Cincho-^inine.  {^"^-^^^l Xt'""" 
"In  one  hundred  ounces  of  good  yellow  bark,  wc  obtain  about  two  and  three- 
iourths  ounces  of  qulnia  and  two  ounces  of  cinchonia,  with  variable  amounts  of  the 
other  principles,  but  less  than  the  two  named." 
We  answer  to  this,  that  cincho-quinine  is  not  a  representative  ot 
^uch  a  bark  ;  that,  to  the  contrary,  it  consists  mainly  of  cinchonia  and 
its  sulphate,  and  that  it  contains  less  than  i  (one)  per  cent,  of  quinia. 
2.  In  their  circular  (described  as  No.  i)  the  manufacturers  state  : 
"CiNCHO-QuiNiNE  holds  all  the  important  constituents  of  bark  in  their  alkaloidal 
-conditions.  It  contains  no  sulphate  of  cinc'honine  or  sulphate  of  quinine^  but  cincho- 
nine,  quinine,  quinidine,  etc.,  without  acid  combinations.  It  contains  no  substances 
but  those  found  naturally  existing  in  bark."" 
In  their  circular  (described  as  No.  2)  the  phraseology  has  been 
changed,  but  the  statement  remains  the  same,  as  will  be  seen  from  the 
following  quotation  : 
"  CiNCHO-QuiNiNE  holds  all  the  important  constituents  of  bark  in  their  alkaloidal 
conditions.  It  contains  no  sulphate  of  cinchonidine,  quinidine  or  quinine,  but  the 
pure  alkaloids  cinchonidine,  quinidine,  cinchonine,  quinine,  etc.,  without  acid  com- 
binations.   It  contains  no  substances  but  those  found  naturally  existing  in  bark." 
To  these  statements  we  answer  : 
1.  Cincho-quinine  contains  sulphuric  acid  and  sulphate  of  ammonium, 
and,  consequently,  does  contain  substances  not  found  naturally  existing 
in  cinchona-bark. 
2.  Cincho-quinine  does  contain  a  portion  of  alkaloids  in  acid  com- 
bination, chief  among  which  is  sulphate  of  cinchonia. 
Louis^-ville,  Ky.,  March  15M,  1875.  # 
APPENDIX. 
Circular  No.  I  was  found  inside  the  blue  wrapper  and  enveloping 
our  sample  of  cincho-quinine  No.  2.  It  consists  of  two  large  pages, 
each  containing  three  columns  of  printed  matter.  The  centre  column 
of  the  first  page  contains  the  cut  of  a  sealed  bottle  of  cincho-quinine. 
This  page  contains,  besides  extracts  from  letters,  formulas  and  methods 
of  using  cincho-quinine,  the  following  : 
"  CINCHO-QUININE 
holds  all  the  important  constituents  of  bark  in  their  alkaloidal  conditions.  It  con- 
tains no  sulphate  of  cinchonine  or  sulphate  of  quinine,  but  cinchonine,  quinine,  quin- 
idine, etc.,  without  acid  combinations.  It  contains  no  substances  but  those  found 
naturally  existing  in  bark. 
"  Its  cost  is  but  little  more  than  half  that  of  sulphate  of  quinine,  and  It  Is  pro- 
nounced equally  efficient  by  a  large  number  of  distinguished  physicians  in  all  parts 
of  the  country.    It  has  but  a  slight  bitter  taste." 
