■''"-IZ'S;!!"- }    Salicylate  and  Carbolate  of  ^inia.  3  5 1 
soluble  in  water,  and  soluble  in  alcohol,  which  is  not  crystallizable. 
The  author  of  this  paper,  on  the  contrary,  states  that  an  aqueous  solu- 
tion of  hydrochlorate  of  quinia  gives  in  the  cold  with  salicylate  of  am- 
monia (prepared  from  Kolbe's  salicylic  acidj  a  cheesy  precipitate  of 
salicylate  of  quinia,  which  can  afterwards  be  obtained  crystallized  from 
alcohol  in  wonderfully  fine,  perfect  prisms  in  concentric  groups.  The 
same  compound  is  formed  when  an  alcoholic  solution  of  quinia  is 
mixed  with  an  alcoholic  solution  of  salicylic  acid  to  complete  saturation, 
and  the  alcohol  is  afterwards  slowly  evaporated. 
The  salicylate  of  quinia  is  anhydrous.  A  determination  of  the  quinia 
by  the  author  gave  the  formula  C20H24N2O2,  C^HgOg.  The  salicylate 
of  quinia  dissolved  in  a  small  quantity  of  water,  upon  the  addition  of 
some  dilute  hydrochloric  acid,  and  was  precipitated  with  ammonia.  The 
resulting  precipitate  of  quinia  was  collected  upon  a  filter,  and  the  quinia 
<lissolved  in  the  ammoniacal  filtrate,  extracted  by  means  of  ether.  The 
above-mentioned  formula  required  70*  12  per  cent,  of  quinia.  The  first 
experiment  gave  69*66  percent.,  the  second,  70-17  per  cent. 
Salicylate  of  quinia  dissolves  in  225  parts  of  water  at  16°  C,  in  20 
parts  of  90  per  cent,  (by  volume)  alcohol  at  13°  C,  and  in  120  parts 
of  ether  at  16°  C. 
Since  the  crystallized  salicylate  of  quinia  could  be  so  easily  obtained, 
the  author  turned  his  attention  to  the  carbolate,  which  has  already  for 
some  time  been  in  no  inconsiderable  demand  for  medicinal  purposes, 
but  which  hitherto  has  only  been  met  with  in  pharmacy  in  a  pulverulent 
form,  and  of  varying  composition  and  properties.  He  reports  that  he 
has  succeeded  in  preparing  the  carbolate  of  quinia,  both  from  water 
and  from  alcohol,  in  slender  acidular  crystals.  Dried  at  130°,  the 
carbolate  gave  the  formula,  C2oH2^N202,  CgHgO.  This  formula  re- 
quires 77*51  per  cent,  of  quinia.  Three  analyses  gave  respectively, 
77*52,  77*32  and  77*88  per  cent. 
Carbolate  of  quinia  dissolves  in  400  parts  of  water  at  16°  C,  in  80 
parts  of  90  per  cent,  alcohol  at  13°  C,  and  slightly  in  ether. 
If  it  could  be  assumed  that  the  quinia  salts  of  salicylic  and  carbolic 
acids  have  a  similar  therapeutic  action,  then  the  greater  solubility  of 
the  salicylate  would  gain  for  it  the  preference.  In  any  case  the  author 
considers  that  henceforth  for  the  carbolate  only  the  definite  crystallized 
compound  should  be  used  in  medicine. — Pharm.  Journ.  and  Trans. ^ 
June  I2th,  1875. 
