Am- J°ur  Pharm. )  Studies  on  Licorice  Root.  4%l 
July,  1921..  ) 
Appendix  A  and  Appendix  B. 
Four  closely  printed  pages  of  literature  references. 
Appendix  C. 
Elaborate  statement  covering  four  pages,  summarizing,  in  tabu- 
lar form,  all  of  the  conditions  and  results  associated  with  the  twenty- 
seven  methods  for  determining  glycyrrhizin  in  licorice  extract,  which 
the  author  has  discussed. 
P.  A.  Houseman. 
May,  1 92 1. 
Camden,  N.  J. 
MacAndrews  &  Forbes  Co., 
STUDIES  ON  LICORICE  ROOT  AND  LICORICE  EXTRACT. 
By  Percy  A.  Houseman,  Ph.  D.,  F.  I.  C. 
Part  3. 
Previous  papers  on  this  subject  by  the  author  have  appeared  in 
this  Journal,  December,  19 12,  and  March,  19 16.  The  present  ar- 
ticle is  published  in  connection  with  a  translation  which  I  have  made 
of  an  article  by  Linz  (Arch,  der  Pharm.,  1916,  254,  65  and  204),  en- 
titled ''Comparative  Researches  on  the  Methods  Proposed  for  the 
Estimation  of  Glycyrrhizin  in  Licorice  Extract."  This  (abridged) 
translation  appears  in  two  instalments  in  this  Journal,  June,  192 1, 
and  in  this  issue. 
The  article  of  Linz  is  so  exhaustive  that  it  merits  detailed  ex- 
amination. Linz  subjects  to  critical  experimental  examination, 
twenty-seven  methods  which  have  been  proposed  for  the  determina- 
tion of  glycyrrhizin  in  licorice  extract,  and  two  methods  proposed 
for  glycyrrhizin  in  root.  Accepting  what  he  considers  the  desirable 
features  of  the  best  methods  put  forward  for  licorice  extract,  Linz 
compiles  a  method  of  his  own. 
The  present  writer  agrees  with  nearly  all  of  the  criticisms  made 
by  Linz.  Linz  points  out  that  all  of  the  analytical  methods  proposed 
weigh  only  a  more  or  less  crude  glycyrrhizin.  He  rightly  condemns 
the  use  of  an  ammoniacal  solvent  on  the  original  licorice  extract, 
and  approves  an  aqueous  solution,  followed  by  the  addition  of  alco- 
