Amjui°y r'i92iarm' }        Standardization  of  Adrenalin.  515 
Name  Where  From 
Wisconsin    1 
Indiana   T   1 
North  Carolina    2 
Maryland   2 
Mexico    1 
Nicaragua    1 
Delaware   1 
New  York   1 
Total   238 
ABSTRACTED  AND  REPRINTED 
ARTICLES 
STANDARDIZATION  OF  ADRENALIN* 
An  extremely  interesting  paper  on  the  necessity  of  the  physi- 
ological standardization  of  adrenalin,  and  of  preparations  of  the 
suprarenal  gland,  was  presented  by  M.  M.  TifTeneau  at  a  recent  meet- 
ing of  the  Society  of  Pharmacy  of  Paris.  M.  Tiffeneau  commenced 
by  stating  that  of  recent  years  adrenalins  of  varying  degrees  of  pur- 
ity had  been  placed  on  the  market,  and  that  he  had  had  occasion  to 
analyze  products  containing  40  and  as  much  as  60  per  cent,  of  for- 
eign bodies,  mostly  consisting  of  ammonium-magnesium  phosphate. 
M.  Gerard,  chief  of  the  therapeutic  laboratory  of  the  faculty  of  med- 
icine, even  found  a  preparation,  sold  under  the  name  of  adrenalin, 
which  contained  no  trace  ^whatever  of  the  active  principle  of  the  sup- 
rarenal, and  was  devoid  of  any  specific  action.  On  the  other  hand,  he 
had  met  with  adrenalins  which,  while  proving  to  be  chemically  pure, 
exhibited  only  one-half  of  the  physiological  action  of  the  official 
product.  These  proved  to  be  synthetic  products,  representing  the 
racemic  form  of  adrenalin.  This  variation  in  activity,  and  the  fact 
that  substitutes  are  offered  in  the  place  of  the  official  product,  apart 
from  its  adulteration,  render  it  imperative  to  establish  a  strict  method 
of  physiological  standardization  for  this  important  remedy,  as  it  is 
*Reprinted  'from  Chemist  and  Druggist,  May,  1921. 
