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EXAMINATION  OF  CUBEBS. 
consists  mainly  of  crystallized  cubebin,  surrounded  by  thickened 
oil,  some  fat  and  neutral  resin,  scarcely  any  cubebic  acid. 
The  author  has  made  some  physiological  experiments  upon 
himself  with  the  different  principles  isolated  by  him.  The  vola- 
tile oil  in  doses  of  ten  drops  every  two  hours  produced  sensation 
of  heat  in  the  stomach,  which  diffused  over  the  whole  body,  head- 
ache, loss  of  appetite,  difficulty  in  swallowing,  vomiting,  colic, 
diarrhoea,  painful  urinating,  sleeplessness. 
The  extractive  (10-2  grm.  in  48  hours)  and  cubebin  (0-2  to  1*0 
grm.  six  times  daily)  were  without  any  influence. 
The  neutral  resin  produced  sensation  of  warmth  in  the  stomach, 
little  headache  and  colicy  pains,  but  a  considerable  diuresis  free 
from  pain ;  the  acid  resin  had  similar  effects,  but  appeared  to  be 
more  powerfully  diuretic.  The  appetite  was  decreased,  and 
eructations  frequent ;  stool  and  sleep  normal. 
Some  therapeutical  experiments  were  made  by  a  friend  of  the 
author's  in  a  military  hospital. 
Two  cases  of  recent  infection  were  treated  for  eight  days  with 
eight  drops  of  oil  of  cubebs  four  times  daily ;  physiological  ef- 
fects as  described  before.  No  effect  on  the  disease  ;  simple  in- 
jections produced  cures  in  a  few  days. 
One  case,  having  been  treated  for  three  days  with  injections, 
was  now  given  the  extractive,  one  grm.  four  times  daily  for  eight 
days  ;  symptoms  of  disease  rather  aggravated. 
Two  recent  cases  took  0*5  grm.  cubebin  ten  times  daily ;  dose 
increased  on  the  third  day  to  one  grm.,  on  sixth  day  to  two  grm. 
After  eight  days  no  effect  upon  the  organism  or  the  disease. 
The  resins  were  given  in  pills  each  containing  0*05  grm.  Two 
cases  took  five  times  daily  five  pills,  on  the  second  day  eight 
pills,  each  succeeding  day  two  more  (5  times  20  pills  on  the  8th 
to  the  11th  day.)  The  diuretic  effect  was  apparent  on  the  third 
day  ;  sense  of  warmth  in  the  stomach  commenced  and  increased, 
also  burning  sensation  on  urinating.  External  treatment  was 
then  resorted  to,  and  both  cases  discharged  as  cured  after  five 
and  seven  days. 
The  acid  resin  was  given  in  the  same  dose  and  with  the  same 
diuretic  effect,  which  was  less  apparent  in  a  chronic  case. 
Of  the  constituents  of  cubebs,  therefore,  the  two  resins  only 
