CHLORODYNE. 
263 
the  cinchonae  under  glass.  To  neglect  this  would  be  to  ensure 
failing  in  the  undertaking. — Pharmaceutical  Journal,  London, 
January,  1870. 
CHLORODYNE. 
By  Edward  Smith,  F.C.S. 
Judging  from  the  papers  that  have  recently  appeared  in  the 
"Pharmaceutical  Journal,"  it  would  seem  that  there  still  exist 
great  doubts  as  to  the  actual  composition  of  this  popular  remedy. 
There  have  been  published  two  formulae  for  the  preparation  of 
chlorodyne, — one  known  as  Dr.  Ogden's,  and  quoted  by  Royle 
in  his  "Materia  Medica,"  the  other  to  be  found  in  Squire's 
"  Companion,"  and  two  more  distinct  and  divergent  formulae 
can  hardly  be  conceived.  It  may  be  worth  while,  perhaps,  to 
put  them  side  by  side. 
Dr.  Ogden's  (Royle). 
R  ^ther.  Chlor.  Z] 
Chloroform  ^vj 
Tinct.  Capsici  5ss 
01.  Month.  Pip.  gtt.  ij 
Morph.  Mur.  gr.  viij 
Acid.  Perchlor.  gtt.  xx 
Tinct.  Cannab.  Ind.  3j 
Theriacae  3j 
Acid.  Hydrocy.  Scheele  v^i 
Squire's  (Companion). 
R  Chloroform  ^iv 
^ther 
Sp.  V.  Rect.  ^iv 
Theriacae  ^iv 
Ext.  Glycyrrh.  Jiiss 
Morph.  Mur.  gr.  viij 
01.  Month.  Pip.  ni^  xvj 
Syrupi  ^xviiss 
Acid.  Hydrocy.  dil.  ^ij. 
xij. 
Dr.  Ogden,  I  believe,  published  his  formula  as  resulting  from 
analysis,  and  Squire  says  his  formula  has  been  represented  to 
him  as  the  true  one  ;  it  is  plain,  however,  either  that  Dr.  Ogden's 
analysis  is  worthless,  or  that  Squire's  information  is  derived 
from  unreliable  sources.  Dr.  Ogden  gives  the  amount  of  morphia 
as  eight  grains  in  about  nine  drachms  ;  Squire  gives  it  as  eight 
grains  in  about  thirty-five  ounces  !  The  proportion  of  chloro 
form,  too,  differs  enormously.  In  the  first  it  amounts  to  about 
two  thirds,  in  the  latter  to  about  one-eighth.  Dr.  Ogden  says 
nothing  of  ext.  glycyrrh.,  syrup,  sp.  v.  rect.,  or  ether,  and  on 
