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ON  THE  COMPOSITION  OF  CHLORODYNE. 
belladonna,  and  another  with  belladonna  added.  I  selected 
three  male  patients  with  whom  I  found  morphia  to  agree.  They 
were  not  habituated  to  taking  either  chlorodyne  or  morphia, 
neither  had  they  any  organic  disease.  Such,  I  thought,  fair 
subjects  for  notifying  how  far  the  symptoms  produced  by  each 
were  similar  or  dissimilar.  First,  I  will  commence  with  patient 
No.  1.  To  this  man  I  gave  thirty  drops  of  chlorodyne  prepared 
according  to  Mr.  Smith's  form.  In  half  an  hour  he  appeared 
drowsy,  but  did  not  sleep.  There  was  slight  headache  and 
nausea.  I  therefore  repeated  the  dose ;  in  half  an  hour  he  was 
in  a  sound  sleep.  Upon  awaking,  which  he  did  in  seven  hours 
after  taking  the  second  dose,  his  pupils  were  contracted  to  the 
size  of  a  pin's  head.  No.  2.  To  this  man  I  gave  thirty  drops 
of  chlorodyne  prepared  according  to  Mr.  Smith's  formula,  with 
the  addition  of  the  looth  of  a  grain  of  atropine.  In  half  an 
hour,  or  little  more,  he  was  in  a  sound  sleep  ;  and  upon  awaken- 
ing, in  three  hours,  his  pupils  were  dilated.  No.  3.  To  this  man 
I  gave  thirty  drops  of  Dr.  Collis  Browne's  chlorodyne ;  and,  as 
no  sleep  was  produced  in  an  hour's  time, — only  a  feeling  of 
stupor, — I  gave  him  twenty  drops  more.  In  ten  minutes  he 
was  in  a  sound  sleep,  and  continued  so  for  over  five  hours.  When 
he  awoke  his  pupils  were  unaffected  (not  contracted).  The  fol- 
lowing day  I  reversed  the  order  of  things.  To  No.  1  I  gave 
Dr.  Browne's  chlorodyne  ;  no  alteration  of  pupil  (no  contrac- 
tion). To  No.  2  I  gave  Smith's  chlorodyne  ;  the  contracted 
pupil  was  well  marked.  To  No.  3,  Smith's  chlorodyne  with 
atropia ;  the  pupils  were  slightly  dilated.  Hence,  let  me  ask, 
what  does  this  prove  and  impress  upon  the  observer  ?  First, 
that  chlorodyne,  without  belladonna,  does  most  unmistakably 
contract  the  pupil  of  the  eye  when  given  in  a  dose  sufficient  to 
produce  sleep.  Second,  that  chlorodyne  with  belladonna  does 
not  contract  the  pupil.  Thirdly,  that  Dr.  Browne's  chlorodyne  ^ 
does  not  contract  the  pupil  when  given  in  a  sufficient  dose  merely 
to  produce  sleep. 
Again,  with  regard  to  the  action  of  belladonna  upon  the  pupil. 
If  to  a  patient  be  given  the  -^qI^  of  a  grain  of  atropine,  the  pupil 
will  be  dilated  in  ten  minutes.  But  if  to  this  ^^th  of  a  grain  of 
atropine  be  added  the  ^th  of  a  grain  of  morphia,  the  pupil  will 
