442  ON  THE  COMPOSITION  OF  CHLORODYNE. 
can  I  understand  how  he  arrives  at  such  conclusion,  unless  it  be 
from  the  analysis,  of  Mr.  Smith,  which  analysis,  however  perfect 
it  may  be,  does  not  give  us  the  composition  of  clilorodyne.  And 
I  cannot  deny  too  emphatically  the  assertion  of  your  corres- 
pondent when  he  says  that  Dr.  Browne's  chlorodyne  is  merely 
a  disguised  solution  of  morphia.  In  my  former  communication 
I  stated  my  belief  that  Indian  hemp  did  not  enter  into  its  com- 
position. This  I  adhere  to.  I  also  stated  that  I  thought  it 
probable  tobacco  did  so.  This  statement  I  will  not  retract,  al- 
though I  give  it  advisedly,  as  I  have  not  noted  sufficiently  the 
physiological  action  of  this  drug.  Yet,  as  I  do  not  like  to  make 
a  statement  of  this  kind  without  a  practical  reason,  I  will  sug- 
gest to  your  readers  to  test  it  in  this  way : — Place  a  drachm  of 
chlorodyne  in  a  small  porcelain  capsule,  and  expose  it  to  the 
air  at  the  ordinary  temperature  for  twenty-four  or  thirty-six 
hours  until  the  more  volatile  constituents  have  evaporated ;  then 
place  the  capsule  in  a  sand-bath  at  a  temperature  of  140°  F., 
when  a  tobacco-like  odor  will  be  emitted.  By  way  of  experi- 
ment, let  him  try  a  drachm  of  chlorodyne  according  to  Mr. 
Smith's  formula,  and  the  result  will  be  dissimilar.  Lastly,  I 
beg  to  state  that  the  addition  of  belladonna  to  Mr.  Smith's  for- 
mula will  give  results,  both  therapeutical  and  physiological, 
similar  to  Dr.  Collis  BroAvne's  chlorodyne. 
In  this  communication  I  might  have  entered  more  fully  into 
the  symptoms  of  those  patients  upon  whom  I  experimented,  but 
I  have  tried  to  deal  with  the  clearing  up  of  this  matter  in  a  clear 
and  practical  manner.    The  form  that  I  have  adopted  for  some 
time  past  is  as  follows  : — 
R     Belladonnge  Extracti       .        .  .  5ij 
Morphise  Muriatis    .        .        .  •  g^"-  xxx 
^theris  Bectificat  .        .        .  .  f  5viij 
Chloroformi    .        .       .        .  .  f  ^viij 
Acid.  Hydrocyanic,  dil.    .        .  .  f  siv 
Olei  Menthse  Piperitas     .        .  .  gtt.  xxx 
Capsicine        .       .        .        .  •  gi*-  vj 
Misturse  Acacise      ....  5xx 
Caramel         .       .        .        .  •  Sj 
Theriacae        ....  ad  six 
M.  s.  artem. 
