30  Note  on  Warburg  s  Tincture.        {A  jiiSSfyJwof.111" 
NOTE  ON  WARBURG'S  TINCTURE.1 
By  Ferdinand  A.  Sieker. 
The  first  and  second  editions  of  the  National  Formulary  state 
that  "each  fluid  ounce  contains  10  grains  of  quinine  sulfate." 
The  first  edition  of  the  National  Formulary  directs  1,280  grains 
of  quinine  sulfate  in  8  pints  of  tincture,  which  is  equivalent  to 
10  grains  of  quinine  sulfate  in  each  fluid  ounce. 
The  second  edition  of  this  work  directs  100  grammes  (1,543-2 
grains)  of  quinine  sulfate  in  5,000  c.c.  (169-07  fluid  ounces),  which  is 
equivalent  to  9-131  grains  of  quinine  sulfate  in  I  fluid  ounce,  and 
not  10  grains  as  is  intended. 
The  original  formula  for  Warburg's  tincture  directed  10  ounces 
(Troy)  of  "  quinia"  for  the  amount  of  tincture  resulting  from  500 
fluid  ounces  of  proof  spirit.  If  the  yield  is  regarded  as  480  fluid 
ounces,  then  1  fluid  ounce  contains  10  grains  of  "quinia."  There- 
fore, 10  grains  in  I  fluid  ounce  may  be  regarded  as  correct. 
The  amount  of  quinine  sulfate  in  my  formula  (Amer.  Jour. 
Pharm.,  Vol.  72,  p.  573)  is  based  on  the  quantity  directed  by  the 
second  edition  of  the  National  Formulary,  which  is  not  quite  cor- 
rect.   My  formula  should  therefore  be  corrected  as  follows : 
Use  219  grammes  of  quinine  sulfate  instead  of  200  grammes, 
and  24  grammes  of  sulfuric  acid  instead  of  22  grammes. 
The  formula  for  the  modified  tincture  (Amer.  Jour.  Pharm.,  Vol. 
72,  p.  575)  should  therefore  read:  Use  73  grammes  of  each,  cin- 
chonine  sulfate,  cinchonidine  sulfate  and  chinoidine  pure,  instead  of 
66-66  grammes. 
The  quantities  of  fibrous  vegetable  drugs,  etc.,  given  in  my  for- 
mula are  also  somewhat  larger  than  directed  by  the  National  For- 
mulary. The  quantities  are  computed  according  to  the  original 
formula  published  in  England,  where  in  compounding  the  Troy 
ounce  is  used  for  solids  and  the  fluid  ounce  for  liquids. 
Laboratory  of  Lehn  &  Fink,  New  York. 
1  Refer  to  Amer.  Jour.  Pharm.,  1900,  Vol.  72,  pp.  571  to  575. 
