AVa°rch,r9oi.rnJ"i  Chemistry  of  Ipecacuanha,  109 
of  silky  filaments,  which  are  very  readily  soluble  in  water.  The  hy- 
drochloride is  rendered  anhydrous  at  iOO°  C.  The  dried  salt  on 
analysis  gave  12-91  per  cent.  HCl.  Calculated  for  C15H22N02HC1  or 
QoH^N^jO^HCl,  requires  12-83  per  cent.  HCl. 
The  salt  crystallizes  with  greater  facility  in  the  presence  of  an 
excess  of  acid.  On  adding  moderately  strong  hydrochloric  acid  to 
emetine  it  is  immediately  converted  into  a  bulky  mass  of  fine  silky 
crystals,  whereas  the  formation  of  crystals  from  a  neutral  aqueous 
solution  of  the^salt  does  not  take  place  when  the  solution  is  dilute 
until  some  time  has  elapsed  and  the  solution  has  become  concen- 
trated. This  difference  of  behavior  suggested  the  possibility  that 
an  acid  salt  was  formed,  but,  on  analysis  of  the  silky  mass  of  crys- 
tals formed  on  adding  strong  acid  to  the  base,  that  was  not  found  to 
be  the  case.  Considerable  difficulty  was  found  in  obtaining  the 
crystals  which  separated  from  an  acid  solution  in  a  fit  state  for 
analysis  on  account  of  the  large  quantity  of  mother  liquor  absorbed 
by  the  crystals.  Drying  by  heat  gave  a  neutral  salt  containing 
12-83  Per  cent.' HCl  as  required  by  theory.  Analysis  of  the  crys- 
tals well  pressed  on  bibulous  paper  showed  that  no  acid  salt  is  formed, 
but  that  the  presence  of  free  hydrochloric  acid  merely  promotes  the 
crystallization  of  the  neutral  salt.  The  following  results  were 
obtained  with  the  material  thus  imperfectly  dried  : 
Calculated  for 
C15Ho2N02.HC1.3H20 
Found. 
or  C30H44N2O4.2HCl.6H2O. 
73*26 
HCl   . 
10-78 
15*96 
IOO" 
100  * 
The  amount  of  hydrochloric  acid  in  a  dry  acid  salt  having  the 
composition  C15H22N02.2HC1  or  C30H44N2O44HCl  would  be  22-74 
per  cent. 
Emetine  Hydrobromide. — This  salt  can  be  obtained  by  adding 
potassium  bromide  to  a  solution  of  emetine  hydrochloride  or  by 
neutralizing  the  base  with  hydrobromic  acid.  It  crystallizes  in 
tufts  of  silky  needles.  Emetine  hydrobromide  is  now  prepared  on  a 
commercial  scale,  and  a  sample  supplied  to  us  by  Mr.  W.  G.  Whif- 
fen  gave  on  analysis  the  following  results: 
