196       Recent  Literature  Relating  to  Pharmacy.  {K^l^\\J^m' 
and  alkaline  solutions  are  employed.  In  this  work  N/50  sulphuric 
acid  and  caustic  solutions  were  employed  and  the  indicator  solutions 
standardized  by  means  of  the  standard  acid  or  alkali,  as  required. 
The  alkaloids  were  dissolved  in  an  excess  of  the  acid,  50  c.c.  of  %this 
solution  added  to  the  standardized  aqueous  solution  of  the  indicator, 
and  the  excess  of  acid  measured  by  means  of  the  alkaline  solution. 
The  following  indicators,  of  the  usual  strength,  were  employed: 
azolithmin,  iodo-eosin,  methyl-orange,  cochineal,  phenolphtalein, 
lacmoid,  ethyl-orange,  uranine,  hematoxylin,  alkannin  and  Congo 
red.  The  results  obtained  are  summarized  in  extensive  tabulations 
and  the  relative  efficiency  of  the  indicators  is  given  as  follows. 
The  most  suitable  are  printed  in  italics ;  the  next  best  are  enclosed 
in  brackets  ;  (a)  indicates  a  somewhat  indefinite  end  reaction ;  (&) 
the  indicator  is  discolored,  and  (c)  change  of  color  reaction  transi- 
tory. 
Aconitine. — Iodo-eosin,  azolithmin,  hematoxylin,  cochineal. 
Atropine. — Iodo-eosin,  [methyl-orange   (#)],  azolithmin,  hema- 
toxylin, lacmoid,  cochineal,  uranine. 
Caffeine. — None  are  suitable. 
Cocaine. — Lacmoid,  uranine,  cochineal,  hsematoxylin. 
Codeine. — Iodo-eosin,  (azolithmin),  uranine,  hematoxylin,  cochi- 
neal, lacmoid. 
Coniine. — Iodo-eosin,  (methyl  orange),  uranine,  [azolithmin  (#)], 
hematoxylin  (c),  (alkannin),  cochineal,  lacmoid,  Congo  red. 
Emetine. — Iodo-eosin,  [azolithmin  [uranine  (ay],  [hematoxy- 
lin {ay],  cochineal,  [lacmoid  (£)]. 
Morphine. — (Iodo-eosin),  cochineal,  lacmoid. 
Narceine. — None  are  suitable. 
Narcotine. — (Methyl  orange),  lacmoid. 
Papaverine. — Lacmoid. 
Pelletierine. — (Iodo-eosin),  uranine,  cochineal,  [lacmoid  (£)], 
[azolithmin  (£)]. 
Quinine. — Azolithmin,  uranine,  hematoxylin  (c),  lacmoid,  in  pres- 
ence of  ether. 
Sparteine. — Azolithmin,  (uranine),  hcematoxylin,  phenolphtalein, 
alkannin. 
Strychnine. — Iodo-eosin,  azolithmin,  (uranine),  hematoxylin, 
cochineal,  (lacmoid). 
Thebaine. — Iodo-eosin,  uranine,  (hematoxylin),  cochineal,  lacmoid 
(a). 
