270 
Developments  in  Organic  Compounds.  { 
Am.  Jour.  Pharm. 
June,  1901. 
iodin  should  be  in  a  sufficient  unstable  condition  so  that  under  in- 
fluence of  the  secretions  it  will  be  slowly  liberated. 
The  toxic  effect  of  aliphatic  chlorinated  products  stands  in  direct 
ratio  to  their  narcotic  action  ;  the  more  chlorine  introduced  the 
greater  the  toxicity,  when  otherwise  no  change  in  stability  and 
physical  relationship  has  occurred.  Thus  methylene  chlorid 
(CH2C12)  is  less  toxic  than  chloroform  (CHC13)  and  is  a  lighter  anaes- 
thetic. On  the  other  hand,  tetra  chlor  methane  (CC14)  is  far  more 
dangerous  than  chloroform.  The  simpler  aldehydes,  as  formalde- 
hyde (HCHO)  or  acetaldehyde  (CH3CHO)  are  of  an  irritating 
nature.  This  character  disappears  upon  the  introduction  of  chlorin, 
attaining  a  maximum  hypnotic  effect  in  the  tri  chlor-substitution 
product  (chloral  CG3CHO).  The  antiseptic  effect  of  the  benzole 
derivatives  increases  with  addition  of  halogens ;  thus  para-chloro- 
phenol 
are  all  active  antiseptics,  the  latter  being  the  most  active. 
The  iodin  substitution  products  play  a  still  more  important  part 
among  the  antiseptics,  as,  for  example  iodoform  (CHI3),  iodo  cresol 
trichloro-phenol 
and  tri  bromo-phenol 
OH 
Traumatol  C6HI3/ 
OH 
CH3 
tri-iodo  cresol 
Losophan  C6HI. 
