A.m.  Jour.  Pharm. 
July,  1901. 
Developments  in  Organic  Compounds. 
335 
C 
HoC 
(CH3)2C 
H 
OH 
CH2 
C(CH3)2 
N  —  CH3 
Triaceton  alkamin. 
H2C 
CH  .  OH 
CH9 
(CH3)2C  N  /  CCH3 
NH 
Vinyl  diaceton  alkamin. 
C 
/COOCH, 
\0— C6H5CO 
Eucai?i  "A" 
Benzovl-methyl 
Tetra-m  ethyl 
Hydro-piperidin 
Carboxy-methyl 
Ester. 
H 
\0— CH 
XOH— CO 
/  upthalmin 
CH.O— C6H5CO 
Eucain  "B" 
the  local  anaesthetics  eucain  "  A"  and  eucain  "B"  and  the  myotic 
euphthalmin 
Eucain  A,  which  is  closely  related  to  tropa  cocain,  is  a  local  anaes- 
thetic, it  does  not  produce  a  dilation  of  the  pupil,  however,  its 
irritating  action  on  mucous  surfaces  are  detrimental  to  its  use.  More 
successful  as  a  substitute  for  cocaine  was  Eucain  "  B,"  which  is  free 
from  irritating  action  and  more  active  and  less  toxic  than  the  former. 
Chemically,  eucain  "  B  "  is  the  benzoyl  derivative  of  the  base  vinyl- 
diaceton-alxamin,  and  like  cocain,  it  loses  its  local  anaesthetic  effect 
on  replacing  the  benzoyl  radical  with  an  acetyl.  If  a  mandelic  acid 
radical  (C6H5 — CH(OH)CO)  is  introduced  in  place  of  the  benzoyl  of 
eucain  "  B,"  the  very  active  mydriatic  eupthalmine  results.  The 
hydrochlorid  of  this  base  has  chemically  the  same  relation  to  eucaine 
"B"  as  homatropin  has  to  tropa-cocain,  that  is  euphthalmin  is  the 
hydrochlorid  of  the  mandelic  acid  derivative  of  eucain  "B." 
Einhorn  and  Heinz  have  prepared  various  derivatives  of  the  other 
half  of  the  ecgonine  complex,  namely  hexa-hydrobenzole.  They 
found  that  all  the  esters  of  the  aromatic  hydroxy-amido  acids  pos- 
sessed local  anaesthetic  properties,  particularly  so  the  methyl  ester 
of  para-amido-meta-oxy-benzoic  acid  (C6H3(OH)(NH2)COOCH3) 
which  is  called  orthoform. 
