490  American  Pharmaceutical  Association.  {A^ciXr.Pi9oi.m' 
The  Alkaloids  of  Sanguinaria  Canadensis. 
By  R.  Fischer. 
The  author  separated  the  alkaloids  of  this  drug,  chelerythrine, 
sanguinarine,  protopine  and  /3  and  y  homochelidonine  according 
to  a  new  process.  Chelerythrine  (C^H^NC^),  which  before  had 
always  been  prepared  containing  one  molecule  of  alcohol,  was  ob- 
tained by  precipitating  from  acid  solution  with  ammonia  and  dis- 
solving the  dried  precipitate  in  toluol,  as  a  crystalline  body  melting 
at  263°-264°,  whereas  the  alcohol  containing  base  melted  at  203 °. 
Since  analyses  of  this  body  gave  too  high  results  in  N,  Na2COs 
was  used  as  a  precipitating  agent.  Crystals  melting  at  2570  were 
obtained,  which  contained  one-half  molecule  of  toluol  of  crystalli- 
zation, and  upon  analysis  were  found  to  correspond  best  with  the 
formula  (C21H17N04)2.  H20  -J-  C6H5CH3.  The  analysis  of  san- 
guinarine corresponded  best  with  the  formula  of  Kbnig,  C20H15 
N04+^C2H6OH. 
Both  ft  and  y  homochelidonine  were  found  in  sanguinaria,  differ- 
ing in  crystallographic  form  as  well  as  in  m.  p.  Upon  closer  investi- 
gation the  author  concludes  that  the  two  are  undoubtedly  physical 
isomers.  Depending  upon  the  precipitating  agents  employed,  as 
well  as  upon  the  temperature,  concentrations  and  nature  of  the 
solvent,  either  the  one  or  the  other  of  the  two  forms  would  be 
obtained.  The  change  from  the  y  to  the  ft  homochelidonine  was 
quantitatively  accomplished.  The  reverse  process  was  only  partially 
successful.  j9  homochelidonine  melts  at  1590  and  was  never  found 
to  crystallize  with  alcohol  of  crystallization,  y  homochelidonine  melts 
at  1690.  It  sometimes  crystallizes  with,  sometimes  without  alcohol 
and  acetic  ether  of  crystallization. 
Does  Argemone  Mexicana  Contain  Morphine  ? 
By  Julius  O.  Schlotterbeck. 
The  author  has  found  the  alkaloids  protopine  and  berberine,  but 
no  morphine. 
Contribution  to  the  Chemistry   of  Stylophorum  Diphyllum. 
By  J.  O.  Schlotterbeck  and  H.  C.  Watkins. 
The  authors  have  isolated  the  alkaloids  chelidonine,  stylophine, 
protopine,  diphylline  and  sanguinarine. 
