i6o  Antidotes.  {^iZis^so^^ 
It  is  necessary  to  add  that  in  flasks  differing  from  the  others  only  in 
the  absence  of  pepsin  no  liquefaction  took  place. 
To  test  a  pepsin,  therefore,  I  should  take  of  hydrochloric  acid  of  the 
strength  of  3  grams  of  HCl  per  liter  25  cc;  then  5  grams  of  moist 
fibrin  strongly  dried,  and  add  to  several  flasks  so  prepared  quantities  of 
pepsin  ranging  from  O'lO  to  0'6o  gram.  These  should  be  heated  to 
50°C.,  for  it  has  been  seen  that  four  times  as  much  pepsin  would  be 
required  at  40°C.,  which  would  be  an  useless  waste.  Agitate  every 
half  hour  until  the  complete  solution  of  the  fibrin,  and  then  every  hour. 
A  good  pepsin  ought  not  to  give  a  precipitate  with  nitric  acid  after 
twelve  hours'  heating  in  flasks  containing  25  to  30  centigrams,  and 
after  six  hours  in  those  containing  50  to  60  centigrams.  The  nitric 
acid  should  be  added  drop  by  drop  to  10  cc,  for  example,  of  the  solu- 
tion, and  not  the  slightest  turbidity  should  be  produced  in  the  liquor  at 
the  moment  of  adding  it. 
In  these  experiments  I  have  for  some  time  used  a  fibrin  of  mutton 
washed  until  it  has  become  white  and  preserved  in  pure  glycerin. 
When  required  for  use  it  is  washed  with  plenty  of  water. 
In  subsequent  communications  I  shall  show  the  action  which  a  num- 
ber of  bodies  exercise  upon  the  peptic  and  diastastic  ferments. — Pharm. 
Jour,  and  Trans. ^  Jan.  24,  1 880,  from  Jour,  de  Pharm.  et  de  Chimie^ 
5th  ser.,  vol.  i,  p.  82. 
ANTIDOTES. 
By  Dr.  Th.  Schlosser. 
Translated  from  "  Zcschr.  d.  Allg.  Oest.  Apoth.  Ver     1880,  Nos.  i  and  2,  by 
Louis  VON  COTZHAUSEN,  Ph.G. 
In  order  to  supply  the  demand  for  a  reliable  table  of  antidotes  the 
author  publishes  the  following,  and  at  the  same  requests  others  to  assist 
in  improving  and  completing  the  formulas. 
General  Remark. — An  emetic  is  unnecessary  when  the  poisoned 
patient  has  already  vomited  freely. 
Antidotes  for : 
I.  Aconitia.  |  Tlien  : 
R     Cupri  sulph.,         .  .      I'o  Acid,  tann.,  .  .  4*0 
Aquas  dest.,     .  .  40'o 
Dissolve. 
S  :  Emetic  5  give  half,  and  balance,  if 
Aquae  dest.,     .  .  200-0 
Syr.  simpl,,  .  .  50*0 
M.  S  :  Tablespoonful  every  five  min-^ 
necessary,  in  five  minutes.  |  utes. 
