A.m.  Jour.  Pharm  ) 
April,  iSSo.  J 
Albuminate  of  Iron, 
179 
<of  iron)  of  the  albuminate,  but  the  latter,  after  its  formation,  does  not 
appear  to  become  changed  in  its  composition  by  fractional  washings. 
Merck^  recommends  the  method  of  Dr.  Hoffmann  (?)  for  preparing 
<dry  albuminate  of  iron.  Fifteen  parts  crystallized  ferric  chloride  (con- 
taining 20  per  cent.  Fe),  or  20  parts  liquor  ferr.  sesquichlor.  (Phar. 
Ger.),  are  dried  with  10  parts  dextrin  at  40°  to  50°C.  (=104°  to  122° 
F.),  and  pulverized ;  then  80  parts  pulverized  egg-albumen  are  mixed 
with  it.  He  describes  it  to  form  Inminous  brownish-red  crystals  (?), 
-not  hygroscopic,  soluble  in  50  parts  cold  water,  and  most  readily  at  a 
temperature  of  30°  to  35°C.  (=86°  to  95°F.).  A  slight  deposit  may 
form  on  standing,  which  is  readily  dissolved  by  a  few  drops  of  hydro- 
<^hloric  acid. 
Donit%'^  gives  the  following  formula:  The  white  of  one  or  two  eggs 
is  thoroughly  mixed  with  about  150  cc.  water,  and  a  solution  of  six 
'drops  of  officinal  (Phar.  Ger.  ?)  solution  of  ferric  chloride  in  30  cc.  water 
is  gradually  added,  agitating  vigorously  after  each  addition.  The  tur- 
^bidity  at  first  produced  gradually  disappears  on  the  further  addition  of 
the  ferric  solution,  but  the  addition  of  a  few  drops  of  hydrochloric  acid 
may  be  necessary  if  the  ferric  solution  has  been  added  too  rapidly.  The 
'Solution  is  finally  filtered,  which  it  does  more  easily  than  if  it  is 
attempted  to  filter  the  solution  of  albumen  before  the  addition  of  ferric 
•chloride.  Upon  evaporating  the  solution  at  a  moderate  temperature  a 
|)ermanent  and  readily  soluble  dry  albuminate  is  obtained.  Finally, 
Hager^  in  an  Appendix  (p.  1338)  to  his  recently-completed  "  Hand- 
buch  der  Pharmaceutischen  Praxis,"  gives  the  following  formula  for 
'''ferrum  albuminatum  saccharatum " :  100  cc.  albumen  (from  5  hen's 
•eggs)  are  vigorously  shaken  with  400  cc.  water,  the  solution  is  strained 
without  expression,  mixed  with  250  cc.  of  a  cold  saturated  solution  of 
common  salt,  and  then  with  40  cc.  liq.  ferri  sesquichlor.  (Phar.  Ger.) 
diluted  with  160'  cc.  water.  After  about  half  a  day,  the  mixture  is 
"diluted  wilh  3  liters  of  water,  well  shaken,  the  precipitate  collected 
upon  a  muslin  strainer,  washed  with  water,  etc.  The  well-drained 
magma,  which  when  dry  amounts  to  about  10  grams,  is  mixed  with 
60  grams  of  powdered  refined  sugar,  dried  at  the  temperature  of  the 
water-bath  on  porcelain  plates,  weighed,  powdered,  and  mixed  with  suf- 
ficient sugar  to  make  100  grams  of  saccharate.  This  contains  0*65  to 
<0'66  per  cent,  ferric  oxide;    the  pure  albuminate  6*5  to  6*6  ferric 
^"Phar.  Zeit.  "  March,  1878. 
-^"Berlin.  Killn.  Wochenschr,,"  Sept..  8,  1879,  p  535, 
