484 
Glycerole  of  Cinchona, 
(  Am.  Jour.  Pharm, 
t       Oct.,  1880. 
The  glycerole  of  cinchona,  of  which  I  am  now  about  to  speak,  is  a 
dense  but  very  clear  liquid,  each  fluidounce  of  which  represents  a  troy- 
ounce  of  the  bark  \  and,  as  there  is  not  the  slightest  deposit  of  any  kind, 
it  contains  all  the  virtues  of  the  bark,  coupled  with  those  of  the  glycerin. 
The  glycerole  of  cinchona  rubra  is  a  very  dense  liquid,  of  a  rich,  deep 
garnet  color,  while  the  glycerole  of  cinchona  calisaya  is  considerably 
lighter  in  color  and  not  so  dense;  this  is  evidently  on  account  of  the 
much  greater  quantity  of  extractive  matter  in  cinchona  succirubra. 
As  the  process  for  making  the  glycerole  of  either  cinchona  succi- 
rubra or  cinchona  calisaya  is  exactly  the  same,  one  formula  will  suffice. 
Take  of    Cinchona  bark,  in  moderately-fine  powder,       .    16  troyounces 
Glycerin,       .  .  .  .         12  " 
Alcohol,  .  .  •  •      3  fluidounces 
Mix  the  liquids,  and  macerate  the  cinchona  for  five  days,  then  pack 
in  a  conical  glass  percolator  and  displace  with  a  menstruum  composed 
of  two  parts  of  alcohol  and  one  of  water.  Collect  first  twelve  ounces 
and  set  aside,  then  continue  percolation  to  exhaustion.  Distil  off  the 
alcohol,  or  evaporate  until  reduced  to  \\  ounces,  and  when  cold  mix 
with  the  first  12  fluidounces;  allow  to  stand  a  few  days,  and  filter. 
As  stated  above,  each  fluidounce  of  this  preparation  represents  one 
troyounce  of  the  bark,  and  therefore  each  teaspoonful  represents  60  gi  ains> 
Sixty  grains  of  cinchona  bark  being  rather  a  large  dose,  and  one  which 
is  seldom  prescribed,  I  have  made  a  glycerole  just  half  the  strength,, 
and  find  it  equally  as  fine  and  much  more  convenient  for  prescribing. 
The  process  is  the  same  as  the  one  previously  given,  with  the  excep- 
tion that  in  this  case  only  one-half  the  quantity  of  cinchona  bark  is 
used,  and  therefore  each  teaspoonful  represents  but  30  grains  of  the 
bark,  which  is  much  nearer  the  average  dose  than  the  former. 
The  glycerole  of  cinchona  is  so  intensely  bitter  that  I  have  endeav- 
ored, by  the  use  of  licorice  and  several  aromatics,  to  make  a  com- 
pound which,  to  some  extent  at  least,  would  be  pleasing  to  the  taste, 
and,  by  compounding  this  with  an  equal  bulk  of  the  glycerole  of  cin- 
chona, quite  an  agreeable  mixture  can  be  made. 
Aromatic  Glycerole  of  Licorice.  ' 
Take  of    Licorice  root,  in  fine  powder,  .  .    2  troyounces 
Cinnamon,  in  fine  powder,  .  .  i 
Cloves,  anise  and  caraway  in  fine  powder,  each,       2  drachms 
Glycerin,  ,  .  .  .4  troyounces 
Dilute  alcohol,  .  ,  .    sufficient  quantity 
