5o8  Preparation  of  Iodine- Iron  Codliver  Oil.  {'''^  ^tZ^^f" 
PREPARATION  OF  IODINE-IRON  CODLIVER  OIL. 
By  S.  Draisma  von  Valaenburg. 
Being  invited  by  the  Rotterdam  Department  of  the  Dutch  Pharma- 
ceutical Society  to  make  the  manner  in  which  I  prepare  my  iodine-iron 
codliver  oil  public,  a  thing  which  I  had  often  thought  of,  but  different 
circumstances  had  up  till  now  prevented  me  from  carrying  out,  I  here- 
with present  to  the  public  the  following  prescription: 
R     lodii,  ....  part  1-25 
Ferri  pulverati,    .  .  •  .      "  2*50 
01.  jecor.  asselli,         '  .  .  "  98*50 
The  iodine  is  thrown  into  a  vessel  filled  with  codliver  oil,  and  by 
constant  stirring  or  shaking  for  some  days  made  entirely  to  dissolve  into 
it,  so  that  the  liquid  when  left  for  some  time  to  itself  has  a  specific 
weight  of  0*932  to  0*937  at  13*5  to  21  °C. 
The  solution  is  now  poured  in  a  vessel  which  is  hermetically  shut, 
and  brought  into  contact  with  iron  by  shaking  or  stirring  it  with  this 
ingredient  for  some  four  hours  until  it  gets  a  purple-violet  color,  and 
after  a  due  shaking  with  solution  of  iodetum  kalicum  and  diluted  starch 
has  lost  the  power  to  produce  a  reaction  on  free  iodine. 
The  liquid  must  now  stand  quietly  for  twenty-four  hours  (the  vessel 
must  be  carefully  shut,  and  nearly  full),  then  shaken  again  for  an  hour 
at  least  till  it  has  been  proved,  after  again  shaking  with  a  little  iodetum 
kalicum  amylum  solution  (also  after  twenty-four  hours)  that  the  pre- 
paration is  wholly  exempt  from  free  iodium,  may  easily  be  made  an 
emulsion,  and  consequently  remain  constant.  The  m'xture  must  now 
stand  till  it  appears  clear,  and  one  must  make  sure  by  specific  weight 
and  analysis  that  the  desired  combination  has  taken  place. 
The  oil  should  be  conserved  in  well-corked  bottles,  filled  to  the  top 
and  of  yellow-colored  glass,  which  must  have  as  little  surface  exposed 
to  the  air  as  is  possible. 
The  bottles  are  supposed  to  be  emptied  in  five  days  ;  scrupulous 
investigations  have  brought  to  light  that  in  this  space  the  air  can  produce 
but  a  very  trifling  change  in  the  oil. 
The  mixture  must  be  of  a  purple-violet  color,  and  should  have  a 
specific  weight  of  0*937  to  0'94.o  at  8  to  13°.  It  should  contain  1*23 
per  cent,  of  iodine  and  about  0*27  per  cent,  of  iron,  both  in  a  chemi- 
cally combined  condition.  The  mixture  will  become  of  a  darker 
color  and  the  quantity  of  iron  greater,  as  the  air  has  had  more  time  to 
form  iron  oxyiodide.     Nothing  of  an  iodine  reaction  must  be  observed 
