RESEARCHES  ON  THE  CONSTITUTION  OF  QUININE.  321 
RESEARCHES  ON  THE  CONSTITUTION  OF  QUININE. 
By  Adolphus  Strecker. 
(Translated  from  the  Annalen  d.  Chem  und  Pharm.,  August,  1854. 
By  J.  M.  Maisch.) 
Concluded  from  page  24(5. 
Iodide  of  ethyle- quinine.  If  iodide  of  ethyle  is  added  to  an 
alcoholic  or  ethereal  solution  of  quinine,  pale  yellow  needles  are 
formed  after  a  few  hour3.  I  have  washed  them  with  ether,  and 
dissolved  them  in  boiling  water,  from  which,  on  cooling,  they  re- 
crystallize  in  thin  needles,  combined  to  semi-spherical  masses. 
The  crystals  are  colorless,  of  a  silky  lustre,  very  light  and  bitter, 
and  without  reaction  on  vegetable  colors.  They  neither  lose 
weight  nor  alter  their  form  at  110°  C. ;  at  a  higher  temperature 
they  melt  without  losing  weight,  but  assuming  a  yellowish  color, 
and  solidify  on  cooling  to  a  glassy  mass;  at  a  still  higher  heat 
they  are  decomposed.  They  are  freely  soluble  in  boiling,  little 
in  cool  water,  and  also  in  alcohol,  but  not  in  ether.  The  iodine 
which  they  contain  can  be  precipitated  as  iodide  of  silver  by  its 
nitrate. 
For  analysis  I  used  crystals  which  had  been  dried  at  100°  C. 
The  combustion  was  attempted  with  oxide  of  copper  and  oxygen, 
the  first  part  of  the  tube  containing  a  roll  of  sheet  copper,  the 
application  of  heat  to  it  was  interrupted  as  soon  as  the  oxygen 
commenced  to  oxidize  the  reduced  copper.  Thus  the  iodine  was 
not  set  free,  but  remained  in  combination  with  copper. 
I.  0.3460  grms.  crystals  gave  0.6975  grms.  carb.  acid,  0.1930  gr.  water, 
II.  0.2864    "       "       «  0.5760    "       "     "  0.1590  " 
III.  0.4257    <<       "        "   0.2080    "    iodide  of  silver, 
which  lead  to  the  formula  C44  H29  N2  O4  I. 
Calculated.  Found. 
I. 
II. 
III. 
44  C 
264 
55.0 
55.0 
54.8 
29  H 
29 
6.0 
G.2 
6.2 
2  N 
28 
5.8 
4  O 
32 
6.7 
1  I 
127 
26.5 
26.4 
480 
100.0 
21 
