RESEARCHES  ON  THE  CONSTITUTION  OF   QUINIA.  325 
enter  in  combination  on  addition  of  iodide  of  ethyle,  not  even 
after  some  time. 
If,  accordingly,  we  may  believe  it  to  be  demonstrated  that 
ethyle-quinine  is  an  ammonium  base,  the  conclusion  is  irre- 
futable that  quinine  belongs  to  the  nitril  bases,  or,  in  other 
words,  quinine  is  a  compound  similar  to  ammonia,  in  which  three 
organic  radicals  have  taken  the  place  of  hydrogen.  From  this 
it  follows  further,  that  the  formula  C40  H24  N2  04  represents  the 
equivalent  of  quinine,  inasmuch  as  it  resembles  one  equivalent  of 
ammonia.  By  the  addition  of  one  equivalent  of  iodide  of  ethyle 
the  triethyleamin  Ae3  N  changes  to  iodide  of  tetraethyleamin 
Ae4  NI,  corresponding  with  the  change  of  quinine  to  iodide  of 
ethyle-quinine.  Those  bases  that  combine  with  one  equivalent 
of  iodide  of  ethyle  must  be  equivalent,  and,  therefore,  quinine 
as  expressed  by  the  formula  C40  H24  N2  04  is  equivalent  with 
Ae3  N,  and  again  this  triethyleamin  is  equivalent  with  H3  N.  If 
the  equivalent  of  quinine  was  C20  H12  N02,  the  iodide  of  ethyle 
quinine  ought  to  be  C2i  Hi7  N02  I,  which  is  contradicted  by  the 
analysis  leading  to  the  formula  C44  H29  N2  0,  I. 
Like  quinine,  ethyle-quinine  combines  with  acids  in  two  pro- 
portions, and  these  salts  we  can  now  designate  as  neutral  and 
acidulous.  The  base  of  ethyle-quinine  has  probably  in  its  free 
state  the  formula  C44  H29  N2  05,  110,  and  ought  to  be  called  the 
hydrated  oxide  of  ethyle-quinine,  for  which,  however,  we  prefer 
the  abbreviation  of  ethyle-quinine. 
In  the  same  way  we  call  the  salts — 
Neutral  sulphate  of  ethyl-quiuiue      C44  H29  N2  O5  ,  SO3 
Bisulphate  of  ethyle-quinine  C44  H29  N2  05  ,  HO,  2S03 
Chloride  of        «  C44  H29  N2  04  ,  CI 
Iodide  of  "  C44  H29  N2  O4  ,  I 
Chloride  of        "       and  platinum  C44  H29  N2  04  ,  Cl-f  HCl+2Pt  Cl2 
We  learn  from  the  above  that  indeed  organic  bases  may  com- 
bine to  form  acid  salts  with  hydrochloric  acid,  and  such  again 
with  two  equivalents  of  chloride  of  platinum.  Most  chemists, 
by  believing  the  proportions  of  organic  combinations  to  be  iden- 
tical with  those  of  organic  bodies,  would  not  recognize  other 
combinations  of  chloride  of  platinum,  except  with  equal  equiva- 
