248 SUBSTANCE ANALOGOUS TO GUN COTTON 
toms disappeared, leaving only a sense of langor and an 
unpleasant sensation about the heart. 
February 20th. — The above experiment was repeated, 
but no new symptoms were produced. The disagreeable 
feelings about the heart, however, were somewhat aggra- 
vated, but soon passed off. 
February 22d. — Having recovered entirely from the for- 
mer experiments, I determined to make another trial, using 
a larger dose, however, than I had done heretofore. The 
pulse was at sixty-six beats per minute, and perfectly regu- 
lar. I took one drop of the tincture, and the pulse in less 
than a minute rose to one hundred and twenty-four beats per 
minute. It was hard, distinct, and almost incompressible. 
The heart labored violently and a lancinating pain passed 
from the region of the heart to the back between the shoul- 
ders. The pain in the head was almost unendurable, par- 
ticularly in the forehead, and the disagreeable feelingsat the 
base of the brain were far more severe than I had yet known 
them. Eyes were injected and seemed to protrude, the pupils 
were somewhat dilated. Flashes of light were almost contin- 
uous and vision of course indistinct. The tongue and mouth 
burned, and the former felt swollen and raw, and was 
affected by spasmodic twitchings. Respiration was not im- 
peded, though there was a sensation of constriction about 
the chest. In two minutes the pulse had fallen to one hun- 
dred beats per minute, and was decidedly intermittent. 
The symptoms gradually disappeared, and in half an hour 
no positively disagreeable sensations remained. The same 
sensation of weariness and oppression about the heart was 
noticed as in former trials. 
I have also the results of several other experiments, but 
as they do not differ materially from those given above, I 
do not think it necessary to detail them. 
February 24th. — Experiment upon a cat. In attempting 
to put this preparation, in substance, into her mouth I acci- 
dentally touched the glass rod upon the end of her nose; 
