44 
APIOL  AS  A  SUBSTITUTE  FOR  QUININE. 
under  like  circumstances,  proves  at  the  same  time  that  the  apiol 
does  possess  a  certain  antiperiodic  value.  None  of  the  many 
substitutes  for  quinine  boasted  of  at  this  day,  have  given  a  greater 
number  of  cures  under  similar  circumstances.  Far  from  reject- 
ing apiol  because  it  does  not  possess  every  possible  virtue,  we 
should  experiment  anew,  and  study  patiently,  and  without  any 
prejudice,  all  of  its  therapeutic  qualities,  and  thus  establish  with 
accuracy  its  relative  position  with  regard  to  the  various  salts  of 
quinia.  It  might  be  then  demonstrated,  that  whilst  apiol  could 
not  be  regarded  as  a  complete  substitute  for  quinia,  yet,  that  it 
would,  greatly  reduce  the  consumption  of  that  costly  agent,  and 
under  favorable  circumstances,  would  answer  the  same  purpose. 
The  society  of  pharmacy  have  thus  reasoned  in  rewarding  the 
authors  of  the  memoir,  and  engaging  them  to  continue  their  re- 
searches. Drs.  Joret  and  Homolle  prosecuting  their  task,  have 
published  a  new  essay  on  apiol  as  a  substitute  for  quinine.  In 
making  this  examination,  they  have  followed  the  programme  laid 
down  by  the  society,  and  constantly  compared  the  therapeutic 
value  of  apiol  with  the  sulphate  of  quinine.  Classifying  intermit- 
tent fevers  according  to  their  degrees  of  violence  and  obstinacy, 
and  recapitulating  the  various  rules  which  ought  to  guide  the 
practitioner  in  the  administration  of  any  febrifuge  remedy,  they 
relate  the  cases  in  which  this  organic  product  gave  the  most 
favorable  results  ;  those  where  the  results  were  only  moderately 
successful ;  those  where  no  effect  was  observed ;  and  lastly,  from 
the  accumulation  of  clinical  facts  collected  by  many  reliable 
observers  in  different  countries  and  climates,  they  have  ascer- 
tained the  actual  antiperiodic  value  of  apiol,  and  its  relative 
value  when  compared  with  the  sulphate  of  quinine.  In  this  way 
they  have  arrived  at  the  following  conclusion  : — 
Apiol  whilst  it  does  not  take  the  place  of  the  sulphate  of 
quinine  in  the  intermittent  fevers  of  hot  climates,  can  be  very 
well  substituted  for  the  quinine  in  the  intermittents  of  more  tem- 
perate latitudes,  as  for  instance  in  France. 
We  proceed  to  give  our  readers  some  extracts  from  this  second 
memoir,  which  we  think  interesting  and  valuable. 
The  various  products  which  were  obtained  by  MM.  Joret  and 
Homolle  from  the  parsley  seed  are  as  follows  : 
