Am.jour.piuu-ni.j  QicanillgS  from  the  German  Journals.  83 
genous,  inactive  substance  (occasionally  this  can  be  obtained  crystal- 
line) ;  warm  96  per  cent,  alcohol  removed  the  coloring  and  bitter 
principles ;  after  evaporating  to  syrupy  consistence  it  was  taken  up 
with  water  and  acidulated  with  sulphuric  acid,  the  precipitate 
collected,  expressed,  dried  at  400  C,  and  extracted  in  a  Soxhlet 
apparatus  for  some  weeks  with  petroleum-ether  until  the  last  traces 
of  the  above-mentioned  nitrogenous  substance  were  removed  and 
the  residue  exhausted  with  alcohol  or  ether  ;.  from  this  alcoholic  or 
ethereal  solution  there  separated  after  a  time  yellow  crystalline 
masses  which,  recrystallized  several  times  from  ethereal  solution, 
were  found  to  constitute  the  active  principle.  It  is  soluble  in  chloro- 
form, ether,  acetone,  phenol,  acetic  anhydride,  aniline  and  alcohol ; 
almost  insoluble  in  cold  water,  slightly  soluble  in  warm  water ; 
insoluble  in  petroleum-ether,  benzol  and  carbon  disulphide  ;  alka- 
lies and  alkaline-earth  hydrates  dissolve  it  ;  from  neutral  or  alkaline 
solutions  it  is  precipitated  by  neutral  and  basic  lead  acetate,  dialyzed 
iron,  zinc  sulphate,  silver  nitrate  and  a  saturated  solution  of  salt, 
but  not  by  alum,  copper  sulphate  and  platinic  chloride  ;  it  does  not 
reduce  Fehling's  solution  and  does  not  react  with  Millon's  reagent. 
Its  ultimate  analysis,  C  59  98,  H  3-54,  N  4-32,  O  32-16,  leads  to  the 
formula  C32H22N2013.  Physiologically  it  was  found  that  cold-blooded 
animals  were  entirely  indifferent  to  it;  while  in  warm-blooded 
animals  uraemic  intoxication  was  produced  ;  in  this  respect  aristolo- 
chin  is  a  much  more  powerful  agent  than  any  other  substance ;  it 
resembles  aloin  in  its  action  upon  the  kidneys,  but  is  about  ten  times 
more  poisonous — it  is  probable  that  given  to  man  it  may  act  as  a 
cathartic. — (Arch.f.  exper.  Pathol,  u,  Pkarm.)  Apoth.  Ztg.,  1891,  642. 
Arsenical  cod-liver  oil,  upon  the  request  of  a  specialist  in  chil- 
dren's diseases,  was  prepared  as  follows:  0-5  gm.  arsenious  oxide  was 
warmed  with  20  grams  absolute  alcohol  in  a  small  flask ;  no  solution 
took  place  until  a  small  particle  of  potassium  carbonate  was  added 
when  the  oxide  immediately  dissolved  without  dissolving  the  potas- 
sium carbonate;  after  filtering,  the  solution  was  added  to  1,500 
grams  cod-liver  oil  and  warmed  on  a  water-bath  until  the  alcohol 
was  dissipated.  The  oil  is  perfectly  transparent  and  holds  the 
arsenious  oxide  in  solution ;  30  grams  of  the  preparation  contain  5 
mg.  arsenious  oxide  [this  is  not  correct  if  the  arsenious  oxide  be 
completely  dissolved;  30  grams  will  then  contain  10  mg. — F.  X.  M.] 
and  can  be  given  to  children  in  doses  of  teaspoonful. — 
A.  Janssen,  Pharm.  Ztg.,  1891,  780. 
