112 
Varieties. 
( Am.  Jour.  Ptaarm. 
I       Feb.,  1892. 
uating  from  the  University  of  Pennsylvania  in  1886.  He  then  became  one  of 
Coroner  Ashbridge's  official  physicians,  and  as  such,  in  September,  1890,  made 
post-mortem  examinations  of  several  bodies  at  the  Morgue,  when  one  of  the 
assisting  students  who  was  sewing  up  a  body,  accidentally  punctured  Dr.  Tay- 
lor's left  wrist  with  the  needle  which  he  was  using.  Recognizing  the  gravity 
of  the  occasion,  he  at  once  had  the  slight  wound  cauterized.  For  a  time  it 
gave  him  no  trouble,  but  afterward  abscesses  formed  on  both  arms,  and 
although  the  best  medical  aid  was  called  in  and  he  took  several  trips  for  the 
benefit  of  his  health,  he  obtained  no  relief.  Other  abscesses  formed  in  his 
throat  and  lungs,  and  he  finally  died  from  exhaustion.  At  the  time  of  his 
death  Dr.  Taylor  was  41  years  of  age  ;  he  was  not  married,  but  was  the  main 
support  of  seven  younger  sisters  who  lived  with  him. 
VARIETIES. 
Creasote  in  tuberculosis. — After  nine  years  of  experience  with  small  doses  of 
creasote  (half  a  grain  daily);Dr.  Julius  Sommerbrodt,  in  1887,  expressed  himself 
as  inclined  to  the  belief  that  in  the  first  stages  of  tuberculosis  of  the  lung,  creasote 
can  cure.  After  using  larger  doses  ( 1  to  2  grains  daily)  lasting  cures  were 
recorded  in  long  continued  and  severe  cases,  and  after  continuing  his  observations 
he  reports  (Berl.  kiln.  Wochenschr.,  October  19,  1891)  that  creasote,  in  large 
doses  (1  to  4  grains  per  day),  is,  for  countless  cases,  unsurpassed  as  a  curative 
agent  in  tuberculosis  of  the  lung.  For  a  patient  over  10  years  his  minimal  dose 
is  one  grain  daily,  and  his  maximum  dose  four  grains  daily.  He  has  never  found 
bad  results  from  his  largest  doses.  The  excipient  is  of  importance.  He  prefers 
to  give  it  with  cod-liver,  oil  in  gelatin  capsules,  containing  one  grain  of  creasote. 
It  keeps  best  and  is  best  absorbed  and  best  taken  in  this  form.  His  patients  have 
no  .other  medicine.  It  usually  takes  two  or  three  months  before  its  influence  is 
very  noticeable.  Great  numbers  of  his  patients  have  taken  five,  ten,  twenty 
thousand  capsules  continuously  without  a  bad  symptom,  and  with  excellent 
appetites,  and  this  in  itself  is  an  answer  to  the  objection  that  it  injures  the 
stomach. 
Pifierazine,  C4H10N2,  has  the  constitution  of  piperidine,  C5HnN,  in  which 
CH2  has  been  replaced  by  NH  ;  it  has  been  experimentally  used  by  a  number 
of  physicians  in  cases  of  gout  and  of  gravel  and  urinary  calculus,  due  to  uric 
acid  concretions.  Dr.  Heubach  (Centralb.  f.  Physiol.,  Decb.,  1891)  has  given 
it  subcutaneously  in  doses  of  0-5  gm.  four  times  daily,  the  injections  being 
painful,  but  without  causing  abscesses  or  unpleasant  after-effects.  Taken 
internally  in  doses  of  2*5  gm.  it  caused  severe  headache  on  the  following  morn- 
ing, and  in  one  case  vomiting.  Doses  of  1,  gm.  were  taken  regularly  for  several 
days  without  causing  any  derangement.  The  quantity  of  urine  is  not  increased  ; 
it  remains  acid,  and  shows  no  increase  of  N  (urea)  or  of  P205  ;  but  passed  from 
the  fourth  to  the  tenth  hour  after  taking  the  remedy,  becomes  dark  colored  on 
the  addition  of  HC1,  the  coloring  matter  feeing  separable  by  means  of  amy  lie 
alcohol. 
