A\S,!£m'}  Gleanings  from  the  German  Journals.  141 
Antipyrine  benzoate  is  prepared  by  adding  antipyrine  to  a  boiling 
solution  of  benzoic  acid ;  it  melts  below  the  boiling  point  of  water, 
forming  a  yellow  liquid  which  solidifies  to  an  opaque,  crystalline 
mass ;  from  alcoholic  solution  it  is  obtainable  in  small  crystals.  It 
is  almost  insoluble  in  hot  or  cold  water,  but  is  quite  soluble  in 
alcohol  and  ether;  it  has  a  faint  odor  of  benzoic  acid  and  possesses  a 
pungent  taste.  Antipyrine  picrate  can  be  obtained  in  the  same 
manner;  it  forms  a  pale  yellow  powder  having  the  same  solubilities 
but  is  not  so  fusible.  Both  give  with  ferric  chloride  a  red  colora- 
tion.— S.  Cressati  [L  Orosi)  Pharm.  Post,  1892,  93. 
Hydrargyrum  pyroboricum,  Hg8407,  is  used  to  some  extent  in  the 
treatment  of  sores ;  a  two  per  cent,  ointment  with  vaselin  or  lano- 
lin as  the  base  is  the  preparation  generally  prescribed  ;  the  salt  is 
made  by  dissolving  76  gm.  crystallized  borax  and  54  gm.  mercuric 
chloride  separately  in  I, COO  gm.  distilled  water;  the  solution  of 
borax  is  added  with  constant  stirring  to  the  mercuric  chloride 
solution,  the  brown  precipitate  formed  rapidly  settles  and  is 
thoroughly  washed  with  water  until  the  washings  give  no  reac- 
tion with  silver  nitrate.  It  must  be  dried  in  the  dark  and  then 
constitutes  an  amorphous  brown  powder,  insoluble  in  water, 
alcohol  or  ether. — V.  Tokayer,  Pharm.  Post,  1892,  156. 
The  alkaloids  in  extract  of  belladonna. — The  experiments  of 
Schiitte  and  Siebert  (Am.  Journ.  Pharm.,  1 891,  602),  proving  that 
the  alkaloids  present  in  the  belladonna  leaves  consist  chiefly  of 
hyoscyamine,  made  it  an  interesting  point  to  determine  if  this  alka- 
loid during  the  manufacture  of  the  extract  changed  to  atropine, 
since  it  has  been  found  that  the  change  can  take  place  by  heating 
to  1000  C.  From  10  grams  of  an  extract,  kept  for  about  eighteen 
months  and  prepared  according  to  the  Netherland  Pharmacopoeia, 
the  crude  alkaloids  were  prepared  and  fractionally  precipitated  with 
auric  chloride ;  the  precipitates  were  recrystallized  from  acidulated 
water  and  dried  at  ioo°  C.  The  first  two  fractions  melted  at 
158-5°  C,  the  third  at  156-5°  C,  the  fourth  fraction  was  so  small 
that  the  melting  point  could  not  be  determined,  but  under  the 
microscope  it  was  found  to  consist  largely  of  hyoscyamine-gold- 
chloride,  whilej.the  atropine-gold-chloride  could  not  certainly  be 
identified.  It  follows,  therefore,  that  the  alkaloid  present  in  the 
extract  was  almost  entirely  hyoscyamine  and  that  no  change  had 
