Am.  Jour.  Phariu.  \ 
March,  1892.  J 
Oleoresins. 
149 
copoeia.  This  presumption  is  rarely,  in  practice,  carried  out.  The 
manufacturers  seeking  a  large  yield  obtain,  by  more  thorough 
extraction  with  ether,  20  to  22  per  cent,  and  separate  but  little  of 
the  fat.  A  sample  of  capsicum  extracted  with  ether,  by  the  U.  S.  P. 
process,  yielded  17-32  per  cent.;  with  acetone  by  percolating  only 
until  2  cc.  of  percolate  was  obtained  for  every  gramme  of  drug  used, 
it  yielded  18-00  per  cent.,  and  with  purified  benzin  under  similar  con- 
ditions 21  per  cent.  By  continuing  the  percolation  until  extraction 
was  complete,  the  yield,  with  acetone  and  benzin,  was  increased  to  25 
per  cent.,  but  the  resulting  oleoresin  was  almost  a  solid,  as  the 
continued  extraction  seemed  to  largely  increase  the  'percentage  of 
palmitin  extracted.  These  oleoresins  made  with  ether  and  acetone 
were  both  entirely  soluble  in  benzin,  it  being  the  only  oleoresin 
made  with  acetone,  which  was  soluble  in  this  solvent.  They  yielded, 
with  alcohol,  solutions  which  were  not  entirely  clear.  From  these 
experiments  it  was  concluded  that  either  acetone,  ether  or  benzin 
will  extract  capsicum,  but  the  percolation  should  not  be  continued 
beyond  obtaining  1-5  cc.  of  percolate  for  each  gramme  of  the  drug. 
The  slight  solubility  of  palmitin  in  alcohol  suggested  that  this 
oleoresin  might  also  be  prepared  by  the  use  of  alcohol.  Fifty 
grammes  of  the  capsicum  was  percolated  with  alcohol  and  yielded  28 
per  cent,  of  extract.  From  this  there  separated  a  resinous  and 
waxy  sediment  almost  insoluble  in  ether.  The  liquid  portion  was 
extracted  by  mixing  with  an  equal  volume  of  ether,  in  which  it  was 
easily  soluble  and  separated  from  the  sediment  by  filtering  through 
absorbent  cotton.  .  This  yielded  an  oleoresin  more  liquid  than 
those  made  with  the  other  solvents  and  exceedingly  hot,  corre- 
sponding to  nearly  14  per  cent,  of  the  drug. 
Oleoresina  Cubebcz. — Powdered  cubebs  thoroughly  extracted  with 
acetone  yielded  25  per  cent,  of  oleoresin.  This  was  of  excellent 
quality,  fully  representing  the  drug,  and  was  not  entirely  soluble  in 
benzin,  but  yielded  clear  solutions,  and  was  readily  soluble  in  ether, 
chloroform,  alcohol  and  glacial  acetic'  acid.  After  a  time,  it 
deposited  some  cubebin,  the  wax,  however,  separated  out  at  once, 
being  left  in  the  still.  Working  on  a  larger  scale  since,  the  yield 
from  two  lots  of  cubebs  have  been  24-1  per  cent,  and  21-75  Per 
cent.,  respectively,  which  agree  with  yields  generally  obtained  by 
the  use  of  ether. 
Oleoresina  Lupulini. — The  yield  of  oleoresin  from  lupulin  is 
variously  stated  as  being  from  50  to  70  per  cent.,  and  must  neces- 
