520 
Gleanings  from  tlie  German  Journals.  { 
Am.  Jour.  Pharm 
Oct.,  1892. 
acid.  (4)  The  extraction  of  the  root  with  ammoniacal  alcohol, 
evaporating  to  dryness  and  exhausting  with  chloroform  also  gave 
low  results;  but  here  the  explanation,  verified  by  experiment,  is  that 
emetine  warmed  with  solutions  of  ammonium  salts  causes  the 
liberation  of  ammonia  and  then  the  alkaloidal  salt  produced  escapes 
extraction  by  the  chloroform.  (5)  A  modification  of  Lloyd's  method 
gave  low  results,  a  residue  almost  black  and  impure,  and  incomplete 
extraction.  This  method,  however,  suggested  the  following  one 
which  gave  the  best  and  most  exact  results.  (6)  It  is  advisable  to 
extract  the  powdered  root  without  drying  it,  since  heating  makes 
the  extraction  of  the  alkaloid  more  difficult ;  moisture  should, 
therefore,  be  estimated  in  a  separate  portion.  1 5  gm.  powdered  ipecac 
are  placed  in  a  bottle  with  148  cc.  90  per  cent,  alcohol  and  2  cc. 
hydrochloric  acid,  sp.  gr.  1-12  (measured  at  150  C),  and  digested, 
with  frequent  agitation,  at  400  C.  for  four  days ;  after  cooling  to 
1 50  C.  100  cc.  are  removed,  mixed  in  a  capsule  with  20  cc.  of  a  10 
per  cent,  alcoholic  lead  acetate  solution  (50  per  cent,  alcohol)  and, 
after  the  addition  of  1*5  gm.  slaked  lime,  evaporated,  with  occa- 
sional stirring,  to  a  pasty  consistency  ;  5  gm.  powdered  glass  are 
then  incorporated,  heating  continued  on  a  water-bath  with  constant 
stirring  until  a  dry  powder  results;  this  is  then  extracted  for  10 
hours  with  chloroform,  the  chloroform  solution  evaporated  in  a 
weighed  vessel,  dried  at  ioo°  C.  and  weighed.  This  gives  a  crude 
alkaloid  which  is  then  dissolved  in  2  cc.  normal  hydrochloric  acid 
the  insoluble  matter  gotten  upon  a  weighed  filter,  thoroughly 
washed,  dried  and  weighed.  The  total  residue  minus  the  weight 
of  the  insoluble  resin  leaves  the  weight  of  the  pure  alkaloid. 
The  percentages  as  given  below  are  calculated  to  dried  drug ;  in 
methods  (4)  and  (5)  after  repeating  the  extraction  and  making  allow- 
ance for^resin  present  the  percentages  agree  closely  with  those  in 
method  (6). 
— G.  Kottmayer,  Pharm.  Post,  1892,  913  and  933. 
SaloUemulsion. — Salol  is  best  taken  internally  in  the  form 
of  an  emulsion,  made  by  melting  10  gm.  salol  in  a  capsule  or  water- 
ipecac.  Per  Cent.  . 
Rio,  3 "09,  3"I2>  3'°° 
Singapore,  .3*04 
Carthagena,  .  2*24,  2' 10 
2b. 
Per  Cent. 
3.             4.            5.  o. 
Per  Cent.  Per  Cent.  Per  Cent.  Per  Cent. 
172         174         2'6o  2'37,  2-24 
—           —            —  2*22,  2 "30 
172,  i-86 
1 '62,  174 
1-23,  1-38 
