Am.  Jour.  Pharrn. 
Nov.,  1892. 
Benzoyl-Pscudotropeine. 
58i 
Liebermann  stated  that  by  the  splitting  up  of  benzoyl-pseudo- 
tropeine  with  hydrochloric  acid  it  was  converted  into  benzoic  acid 
and  a  base  which  he  regarded  as  being  identical  with  that  obtained 
from  hyoscine  by  Ladenburg.  Hesse  has,  however,  found  that  the 
base  produced  from  hyoscine  has  a  different  composition  from 
pseudotropeine,  and  it  has  been  named  by  Hesse  oscine} 
After  separating  the  benzoic  acid,  produced  by  the  action  of 
hydrochloric  acid  upon  benzoyl-pseudotropeine,  and  evaporating 
the  acid  solution  a  crystalline  residue  is  obtained,  from  which  the 
base  formed  by  the  splitting  up  of  benzoyl-pseudotropeine  can  be 
obtained  by  adding  caustic  soda  and  shaking  with  chloroform.  On 
evaporating  the  chloroform  solution  the  pseudotropeine  remains  in 
the  form  of  prisms,  which  gradually  become  moist  on  exposure  and 
melt  at  1080.  In  other  respects  it  agreed  with  Liebermann's 
description,  and  as  the  formula  of  benzoyl-pseudotropeine  is 
C15H19N02  the  base  can  only  have  the  composition  represented  by 
the  formula  C8H15NO,  as  Liebermann  found  was  the  case. 
The  pseudotropeine  hydrochloride  crystallizes,  on  evaporating  the 
water  solution,  in  the  form  of  long  needles  which  rapidly  deliquesce. 
On  adding  to  the  solution  platinum  chloride,  the  platinum  salt  soon 
crystallizes  out  as  orange-red  tabular  crystals  readily  soluble  in 
water.  On  evaporating  the  solution  the  salt  crystallizes  in  fine 
prisms.  In  both  cases  the  crystals  have  a  marked  lustre,  which 
they  rapidly  lose  on  warming  from  loss  of  water  of  crystallization. 
At  ioo°  C.  the  salt  becomes  anhydrous  and  then  it  melts  at  2060  C. 
Analysis  gave  results  agreeing  with  Liebermann's  formula — 
(C8H15NO)2,PtC]6H2  +  4H20. 
The  gold  salt  has  the  form  of  yellow  laminae,  and  melts  at  2020. 
Liebermann  gave  225 0  C. 
Pseudotropeine  combines  readily  with  methyl  iodide,  solidifying 
with  evolution  of  heat.  After  recrystallization  from  water  the  com- 
pound has  the  form  of  colorless  rhombohedral  crystals  generally 
grouped  like  those  of  ammonium  chloride.  It  is  anhydrous  and 
melts  at  2700  C.  The  chloride  has  the  form  of  stout  rhombohedral 
crystals,  which  are  anhydrous,  readily  soluble  in  water,  sparingly  in 
alcohol.  The  platinum  salt  is  anhydrous,  melts  at  21 6°  C,  and 
crystallizes  well  from  hot  water.  Pseudotropinemethylhydroxide 
becomes  brown  on  evaporating  its  water  solution  in  the  exsiccator. 
— Phar.  Jour,  and  Trans.,  Sept.  24,  p.  241. 
1  Pharm.  Journ.,  xxii,  222. 
