AmD°ecr;i89h2arm'}  Gleanings  from  the  German  Journals.  61  [ 
A  chlorine  derivative  of  antipynne,  to  be  used  therapeutically, 
according  to  a  patent  application,  is  made  by  acting  upon  antipyrine 
with  hydrochloric  acid  and  bleaching  powder.  It  has  the  formula 
CnH12H203C]2,  is  insoluble  in  water,  dilute  acid,  ether,  chloroform  and 
ligroin,  but  soluble  in  hot  alcohol  and  glacial  acetic  acid  ;  in  alkalies 
it  is  soluble  with  decomposition ;  heated  to  2280  C.  it  melts, 
charring  and  giving  off  hydrochloric  acid  vapors.  By  heating  in  a 
current  of  chlorine,  or  passing  chlorine  through  the  acetic  acid 
solution  and  by  heating  with  hydrochloric  acid  or  alcohol  to  1 500 
C.  it  is  converted  into  dichlor-methyl-phenyl-pyrazolon  which  then 
can  be  easily  reduced  to  methyl-phenyl-pyrazolon. — Apotheker  Ztg., 
1892,  532. 
Constituents  of  Lolium  temulentum ,  L.— An  analysis  of  the  seeds  of 
this  plant  by  Hofmeister  corrects  the  results  announced  by  Dr.  P. 
Antze  (Am.  Jour.  Pharm.,  1891,  568).  The  volatile  alkaloid  "loliine" 
was  found  to  be  impure  ammonia ;  the  so-called  "  temulentine"  was 
also  found  to  be  a  mixture  containing  some  of  the  narcotic  principle 
which  Hofmeister  isolated  and  called  temuline ;  "  temulentic  acid" 
is  at  present  considered  by  Hofmeister  to  be  a  mixture  of  the  acid 
tartrates  of  ammonium  and  potassium.  Hofmeister's  temuline  is  not 
crystallizable,  is  very  likely  a  pyridine  derivative,  is  soluble  in  water, 
has  an  alkaline  reaction  and  eagerly  absorbs  carbonic  oxide.  The 
crystallized  hydrochlorate  has  the  formula  C7H12N20.2HC1.  The 
amount  of  temuline  present  in  the  seeds  is  approximately  0-06  per 
cent.  The  author  also  determined  the  presence  of  an  acid  contain- 
ing nitrogen,  and  of  an  uncrystallizable  alkaloidal  body  ;  by  decom- 
posing the  platinum  double  salt  of  the  latter,  a  mixture  of  temuline 
hydrochlorate  and  an  uncrystallizable  syrupy  body  were  obtained. 
Physiological  experiments  established  that  temuline  is  a  peculiar 
nerve  poison  causing  stupor  and  paralytic  weakness. — (Arch.f  exp. 
Path)  Apotheker  Ztg.,  1892,  544. 
Dulcine  is  a  product  which,  because  of  its  intense  sweetness  and 
its  non-poisonous  character,  seems  destined  to  become  a  serious 
competitor  of  saccharine ;  it  was  prepared  first  in  1883  and  its  sweeten- 
\j  ing  power  then  recognized  ;  but  the  cost  of  manufacture  was  too 
great.  Patents  have  now  been  applied  for  its  preparation  from 
/-phenetidine  by  the  action  of  ammonia  and  carbon  oxychloride. 
The  chemical  name  for  the  compound  is  p-phenetol-carbamide  and 
its  formula  C6H4  (OC2H5)  NHCONH2.~ Apotheker  Ztg.,  1892,  550. 
