1&4  Federal  Control  of  Therapeutic  Sera.   Mm.  jour,  pharm. 
L  l       April,  1909. 
the  underlying  odoriferous  substance.  "  Intermediaries  "  or  "  blend- 
ing agents  "  are  also  used  and  the  true  final  perfume  effect  often  only 
develops  after  the  mixtures  have  stood  for  a  few  days. 
There  is  no  doubt,  however,  that  the  ionone  synthesis  of 
Tiemann  has  been  the  most  marked  advance  made  in  the  perfume 
field  that  we  have  as  yet  recorded,  and  it  illustrates  well  what 
organic  research  is  capable  of  doing  for  an  important  industry. 
FEDERAL  CONTROL  OF  THE  MANUFACTURE  OF 
THERAPEUTIC  SERA.1 
By  John  F.  Anderson, 
Assistant  Director  Hygienic  Laboratory. 
I  wish  to  speak  especially  of  the  practical  working  of  the  federal 
control  of  the  manufacture  of  therapeutic  sera  as  exercised  by  the 
Public  Health  and  Marine-Hospital  Service  through  the  Hygienic 
Laboratory. 
On  April  I,  1905,  the  standard  unit  for  determining  the  strength 
of  diphtheria  antitoxin  in  the  United  States  was  promulgated ;  it  was 
approved  and  included  in  the  Eighth  Decennial  Revision  of  the 
Pharmacopoeia. 
The  American  standard  unit  for  tetanus  antitoxin  was  promul- 
gated October  25,  1907.  Before  the  diphtheria  unit  was  adopted 
most  of  the  manufacturers  in  this  country  used  the  Ehrlich  unit, 
which  is  of  the  same  value  as  the  American  unit  for  the  standardiza- 
tion of  diphtheria  antitoxin ;  before  the  adoption  of  the  standard 
tetanus  unit  by  the  Public  Health  and  Marine-Hospital  Service  there 
were  as  many  different  units  for  measuring  the  strength  of  tetanus 
antitoxin  as  there  were  producers. 
You  may  be  interested  to  know  how  this  control  is  exercised  by 
the  Public  Health  and  Marine-Hospital  Service  over  the  production 
of  therapeutic  sera.  In  accordance  with  an  Act  of  Congress  ap- 
proved July  1,  1902,  and  the  regulations  framed  thereunder,  all 
persons  or  establishments  engaged  in  the  manufacture  and  interstate 
sale  of  viruses,  serums,  toxins,  and  analogous  products  are  required 
to  be  licensed  by  the  Secretary  of  the  Treasury  upon  the  recom- 
1  Read  before  the  Washington  Branch  of  the  American  Pharmaceutical 
Association,  February,  1909. 
