214 
Tincture  of  Strophantus. 
Am.  Jour.  Pharm. 
May,  1909. 
of  menstruum  for  each  100  grammes  of  seed ;  and  to  be  sure  of 
exhaustion,  in  addition,  there  should  be  several  periods  of  maceration 
of  at  least  eight  hours  each. 
5.  The  minimal  lethal  dose  of  such  a  tincture  should  be  between 
one-thirtieth  and  one-thirty-fifth  of  a  cubic  centimetre  per  kilo  of 
cat,  injected  subcutaneously  {i.e.,  about  forty  cat-units  per  cubic 
centimetre) . 
Cat-units, 
each  c.c. 
1  st 
IOO  c.c. 
2nd 
IOO  c.c. 
3rd 
IOO  c.c. 
4th 
IOO  c.c. 
5th 
IOO  c.c. 
6th 
IOO  c.c. 
7th 
IOO  c.c. 
8th 
IOO  c.c. 
9th 
100  c.c. 
10th 
100  c.c. 
Curve  of  Percolation  of  Two  Tinctures  of  Strophanthus. 
No.  4  and  No.  5. 
Percentage  of  toxicity  per  100  grammes  of  seed. 
0%  3%  6%  9%  12%  14%  17%  20%  23%  25%  28%  31%  34%  36%  39% 
fo         14        28       42       56        70       84       98       112      126      140      154      168       182  196 
( 
■  _> 
/ 
/  / 
/  / 
-f—f — 
6.  To  insure  uniformity  in  the  strength  of  the  tincture,  the 
strength  of  the  seed  should  be  constant.  This  may  be  easily  deter- 
mined by  the  wholesale  house.  Pharmacists  should  demand  stand- 
ardized seeds  of  the  strength  indicated  by  about  400  cat-units  (see 
foot-note,  p.  212)  per  gramme  of  seed. 
